Treating the osteosarcoma (OSA) remains a challenge. Current strategies focus on the
primary tumor and have limited efficacy for metastatic OSA. A better understanding of the …

This review summarizes data on microRNA (miRNA) genomic organization, biogenesis, and
functions in carcinogenesis. The roles of key genes and regulatory miRNAs in molecular …

Despite the clinical implication and high incidence of bone and spinal metastases, the
molecular mechanisms behind prostate cancer metastasis to bone and spine are not well …

Metastasis accounts for most of the deaths from breast cancer and the preference of invasive
breast cancer metastasising to bone has been widely reported. However, the biological …

[Frontiers in Bioscience 18, 1407-1434, June 1, 2013] 1407 BMP-7 counteracting TGF-beta1
activities in organ fibrosis Ralf Weisk Page 1 [Frontiers in Bioscience 18, 1407-1434, June 1 …

The CCN family of proteins includes six members presently known as CCN1, CCN2, CCN3,
CCN4, CCN5 and CCN6. These proteins were originally designated CYR61, CTGF, NOV …

Osteosarcoma (OS) is a rare primary malignant bone tumour arising from primitive bone-
forming mesenchymal cells, with high incidence in children and young adults, accounting for …

No curative treatment options exist once breast cancer metastasizes to bone. This is due, in
part, to an incomplete understanding of how osteolytic cancers interact with bone. Presented …

The CCN family of proteins is composed of six extracellular matrix‐associated proteins that
play crucial roles in skeletal development, wound healing, fibrosis, and cancer. Members of …

CCN3, a member of the CCN protein family, inhibits osteoblast differentiation in vitro.
However, the role of CCN3 in bone regeneration has not been well elucidated. In this study …