Beyond being aging-related diseases, atherosclerosis and osteoporosis share common
pathogenetic pathways implicated in bone and vascular mineralization. However, the …

Bone material strength is determined by several factors, such as bone mass, matrix
composition, mineralization, architecture and shape. From a clinical perspective, bone …

Sclerostin is most recognized for its role in controlling bone formation but is also expressed
in the heart, aorta, coronary, and peripheral arteries. This review summarizes research on …

As a key regulator of bone homeostasis, sclerostin has garnered a lot of interest over the last
two decades. Although sclerostin is primarily expressed by osteocytes and is well known for …

There is cumulating evidence for a contribution of Wnt signaling pathways in multiple
processes involved in atherosclerosis and vascular aging. Wnt signaling plays a role in …

Secondary osteoporosis is a common clinical problem faced by bone specialists, with a
higher frequency in men than in women. One of several causes of secondary osteoporosis is …

Cardiovascular (CV) disease and osteoporosis (OP) have become increasing challenges in
the aging population and even more in patients with inflammatory rheumatic diseases, such …

Osteoporosis and cardiovascular diseases are major public health issues. Bone and
cardiovascular remodeling share multiple biological markers and pathways. Medical …

Background Sclerostin (SC) is a monomeric glycoprotein expressed by osteocytes that
affects bone formation. Recent studies have suggested a potential role for this protein in the …

Background Emerging evidence demonstrates that bone is an endocrine organ capable of
influencing multiple physiological and pathological processes through the secretion of …