Melioidosis

WJ Wiersinga, HS Virk, AG Torres, BJ Currie… - Nature reviews Disease …, 2018 - nature.com
Burkholderia pseudomallei is a Gram-negative environmental bacterium and the
aetiological agent of melioidosis, a life-threatening infection that is estimated to account …

Mechanisms of Antibiotic Resistance in Burkholderia Pseudomallei: Implications for Treatment of Melioidosis

HP Schweizer - Future microbiology, 2012 - Taylor & Francis
Burkholderia pseudomallei is the etiologic agent of melioidosis. This multifaceted disease is
difficult to treat, resulting in high morbidity and mortality. Treatment of B. pseudomallei …

A naturally derived outer-membrane vesicle vaccine protects against lethal pulmonary Burkholderia pseudomallei infection

W Nieves, S Asakrah, O Qazi, KA Brown, J Kurtz… - Vaccine, 2011 - Elsevier
Burkholderia pseudomallei, and other members of the Burkholderia, are among the most
antibiotic-resistant bacterial species encountered in human infection. Mortality rates …

Melioidosis vaccines: a systematic review and appraisal of the potential to exploit biodefense vaccines for public health purposes

SJ Peacock, D Limmathurotsakul, Y Lubell… - PLoS neglected …, 2012 - journals.plos.org
Background Burkholderia pseudomallei is a Category B select agent and the cause of
melioidosis. Research funding for vaccine development has largely considered protection …

Designing the next generation of vaccines for global public health

F Bagnoli, B Baudner, RPN Mishra… - Omics: a journal of …, 2011 - liebertpub.com
Vaccine research and development are experiencing a renaissance of interest from the
global scientific community. There are four major reasons for this:(1) the lack of efficacious …

Novel multi-component vaccine approaches for Burkholderia pseudomallei

L Morici, AG Torres, RW Titball - Clinical & Experimental …, 2019 - academic.oup.com
Burkholderia pseudomallei is the causative agent of melioidosis. Historically believed to be
a relatively rare human disease in tropical countries, a recent study estimated that …

Burkholderia vaccines: are we moving forward?

LC Choh, GH Ong, KM Vellasamy… - Frontiers in cellular …, 2013 - frontiersin.org
The genus Burkholderia consists of diverse species which includes both “friends” and “foes.”
Some of the “friendly” Burkholderia spp. are extensively used in the biotechnological and …

[HTML][HTML] Consensus on the development of vaccines against naturally acquired melioidosis

D Limmathurotsakul, SGP Funnell… - Emerging infectious …, 2015 - ncbi.nlm.nih.gov
Several candidates for a vaccine against Burkholderia pseudomallei, the causal bacterium
of melioidosis, have been developed, and a rational approach is now needed to select and …

Development of capsular polysaccharide-based glycoconjugates for immunization against melioidosis and glanders

MN Burtnick, C Heiss, RA Roberts… - Frontiers in cellular …, 2012 - frontiersin.org
Burkholderia pseudomallei and Burkholderia mallei, the etiologic agents of melioidosis and
glanders, respectively, cause severe disease in humans and animals and are considered …

Exploiting the Burkholderia pseudomallei acute phase antigen BPSL2765 for structure-based epitope discovery/design in structural vaccinology

LJ Gourlay, C Peri, M Ferrer-Navarro… - Chemistry & biology, 2013 - cell.com
We solved the crystal structure of Burkholderia pseudomallei acute phase antigen
BPSL2765 in the context of a structural vaccinology study, in the area of melioidosis vaccine …