NLRP3 inflammasome, an immune‐inflammatory target in pathogenesis and treatment of cardiovascular diseases

Y Wang, X Liu, H Shi, Y Yu, Y Yu, M Li… - Clinical and …, 2020 - Wiley Online Library
Inflammation is an important process involved in several cardiovascular diseases (CVDs),
and nod‐like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a vital …

Fibroblast contributions to ischemic cardiac remodeling

RM Burke, KNB Villar, EM Small - Cellular signalling, 2021 - Elsevier
Conclusions The CF has recently emerged as one of the most phenotypically plastic cells in
the heart, with distinct transcriptional and secretory programs that regulate their essential …

[HTML][HTML] Overview of pyroptosis mechanism and in-depth analysis of cardiomyocyte pyroptosis mediated by NF-κB pathway in heart failure

Z Zhang, Z Yang, S Wang, X Wang, J Mao - Biomedicine & …, 2024 - Elsevier
The pyroptosis of cardiomyocytes has become an essential topic in heart failure research.
The abnormal accumulation of these biological factors, including angiotensin II, advanced …

Emerging cardioprotective mechanisms of vitamin B6: a narrative review

T Kumrungsee, P Zhang, N Yanaka, T Suda… - European Journal of …, 2022 - Springer
Although overt vitamin B6 deficiency is rare, marginal vitamin B6 deficiency is frequent and
occurs in a consistent proportion of the population. The marginal vitamin B6 deficiency …

The Pseudomonas aeruginosa protease LasB directly activates IL-1β

J Sun, DL LaRock, EA Skowronski, JM Kimmey… - …, 2020 - thelancet.com
Abstract Background Pulmonary damage by Pseudomonas aeruginosa during cystic fibrosis
lung infection and ventilator-associated pneumonia is mediated both by pathogen virulence …

Herbal glycosides in healthcare

B Soto-Blanco - Herbal biomolecules in healthcare applications, 2022 - Elsevier
Glycosides represent a large group of secondary metabolic products derived from plants,
demonstrating several known functions, including growth regulation, allelopathy (inhibition …

Constitutive secretion of pro-IL-18 allows keratinocytes to initiate inflammation during bacterial infection

AF Johnson, JS Sands, KM Trivedi, R Russell… - PLoS …, 2023 - journals.plos.org
Group A Streptococcus (GAS, Streptococcus pyogenes) is a professional human pathogen
that commonly infects the skin. Keratinocytes are one of the first cells to contact GAS, and by …

[HTML][HTML] Natural toxins and one health: A review

AR Nwaji, O Arieri, AS Anyang, K Nguedia… - Science in One …, 2022 - Elsevier
Abstract Background The One Health concept considers the interconnectivity, interactions
and interdependence of humans, animals and the environment. Humans, animals and other …

Cardiac glycosides cause cytotoxicity in human macrophages and ameliorate white adipose tissue homeostasis

A Olona, C Hateley, A Guerrero, JH Ko… - British Journal of …, 2022 - Wiley Online Library
Background and Purpose Cardiac glycosides inhibit Na+/K+‐ATPase and are used to treat
heart failure and arrhythmias. They can induce inflammasome activation and pyroptosis in …

The Na/K-ATPase role as a signal transducer in lung inflammation

AR Silva, KFC Souza e Souza, TBD Souza… - Frontiers in …, 2024 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is marked by damage to the capillary
endothelium and alveolar epithelium following edema formation and cell infiltration …