Structure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive review
P Csermely, T Korcsmáros, HJM Kiss, G London… - Pharmacology & …, 2013 - Elsevier
Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …
methods and in rational drug design, the increase in approved drugs in the past decade did …
Network-based methods for human disease gene prediction
Despite the considerable progress in disease gene discovery, we are far from uncovering
the underlying cellular mechanisms of diseases since complex traits, even many Mendelian …
the underlying cellular mechanisms of diseases since complex traits, even many Mendelian …
Prioritizing candidate disease genes by network-based boosting of genome-wide association data
Network “guilt by association”(GBA) is a proven approach for identifying novel disease
genes based on the observation that similar mutational phenotypes arise from functionally …
genes based on the observation that similar mutational phenotypes arise from functionally …
Associating genes and protein complexes with disease via network propagation
A fundamental challenge in human health is the identification of disease-causing genes.
Recently, several studies have tackled this challenge via a network-based approach …
Recently, several studies have tackled this challenge via a network-based approach …
Inferring microRNA-disease associations by random walk on a heterogeneous network with multiple data sources
Since the discovery of the regulatory function of microRNA (miRNA), increased attention has
focused on identifying the relationship between miRNA and disease. It has been suggested …
focused on identifying the relationship between miRNA and disease. It has been suggested …
A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers
C Lefebvre, P Rajbhandari, MJ Alvarez… - Molecular systems …, 2010 - embopress.org
Assembly of a transcriptional and post‐translational molecular interaction network in B cells,
the human B‐cell interactome (HBCI), reveals a hierarchical, transcriptional control module …
the human B‐cell interactome (HBCI), reveals a hierarchical, transcriptional control module …
The power of protein interaction networks for associating genes with diseases
S Navlakha, C Kingsford - Bioinformatics, 2010 - academic.oup.com
Motivation: Understanding the association between genetic diseases and their causal genes
is an important problem concerning human health. With the recent influx of high-throughput …
is an important problem concerning human health. With the recent influx of high-throughput …
Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets
Current work in elucidating relationships between diseases has largely been based on pre-
existing knowledge of disease genes. Consequently, these studies are limited in their …
existing knowledge of disease genes. Consequently, these studies are limited in their …
SemFunSim: a new method for measuring disease similarity by integrating semantic and gene functional association
Background Measuring similarity between diseases plays an important role in disease-
related molecular function research. Functional associations between disease-related …
related molecular function research. Functional associations between disease-related …
[HTML][HTML] A novel approach for predicting microRNA-disease associations by unbalanced bi-random walk on heterogeneous network
J Luo, Q Xiao - Journal of biomedical informatics, 2017 - Elsevier
MicroRNAs (miRNAs) play a critical role by regulating their targets in post-transcriptional
level. Identification of potential miRNA-disease associations will aid in deciphering the …
level. Identification of potential miRNA-disease associations will aid in deciphering the …