Chronic inflammatory diseases are debilitating, affect patients' quality of life, and are a
significant financial burden on health care. Inflammation is regulated by pro-inflammatory …

Neurodegenerative diseases (NDs) are described as multifactorial and progressive
syndromes with compromised cognitive and behavioral functions. The multi-target-directed …

Among 276 herbal extracts, a methanol extract of Castanopsis cuspidata var. sieboldii stems
was selected as an experimental source for novel acetylcholinesterase (AChE) inhibitors …

Almost a billion people worldwide suffer from neurological disorders, which pose public
health challenges. An important enzyme that is well-known for many neurodegenerative …

The treatment of SARS-CoV-2 can be accomplished by effective suppression of its 3CL
protease (3CLpro), also known as the main protease (Mpro) and nonstructural protein 5 …

Monoamine oxidase inhibitors (MAOIs) are a class of drugs that can be used in the treatment
of Parkinson's disease, clinical depression, and anxiety by targeting monoamine oxidase B …

Neurological (such as stroke, Alzheimer's, Parkinson's, epilepsy) and neuropsychiatric (such
as autism, migraine, depression, anxiety, stress) disorders continue to be on rising every …

Monoamine oxidases are mitochondrial enzymes that catalyze the oxidative deamination of
biogenic amines (adrenaline, noradrenaline, serotonin, and dopamine), causing their …

Histamine levels in the human brain are controlled by rather peculiar metabolic pathways. In
the first step, histamine is enzymatically methylated at its imidazole N τ atom, and the …

The reduced level of dopamine at midbrain (substantia nigra) leads to Parkinson disease by
the influence of monoamine oxidation process of monoamine oxidase B (MAO-B) enzyme …