The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …

The blood–brain barrier (BBB) prevents efficient drug delivery to the central nervous system.
As a result, brain diseases remain one of the greatest unmet medical needs. Understanding …

Highlights•Various approaches exist to recreate 2D and 3D structures of the
BBB.•Quantitative barrier functions in some BBB-chips are comparable to in vivo …

Organs-on-chips are microengineered microfluidic living cell culture devices with
continuously perfused chambers penetrating to cells. By mimicking the biological features of …

The blood–brain barrier (BBB) regulates the delivery of oxygen and important nutrients to
the brain through active and passive transport and prevents neurotoxins from entering the …

Over the most recent decades, the development of new biological platforms to study disease
progression and drug efficacy has been of great interest due to the high increase in the rate …

The blood-brain barrier (BBB) is critical for the central nervous system, as its integrity
protects neurons and other brain cells from harmful toxicants and disease-associated …

In contrast to traditional 2D cell cultures, both 3D models and organ-on-a-chip devices allow
the study of the physiological responses of human cells. These models reconstruct human …

Endothelial cells (ECs) are a key cellular component of the vascular system as they form the
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …

Significant advancements in the field of preclinical in vitro blood-brain barrier (BBB) models
have been achieved in recent years, by developing monolayer-based culture systems …