The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …

Tumour-specific antigens have been an area of interest in cancer therapy since their
discovery in the middle of the 20th century. In the era of immune-based cancer therapeutics …

Simple Summary Diffuse large B-cell lymphoma (DLBCL) is the most common type of
malignant lymphoid neoplasm and includes morphologically and molecularly …

Glioblastoma (GBM) is the most lethal primary brain tumor in adults and harbors a
subpopulation of glioma stem cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), a histone …

During innate immune responses, myeloid differentiation primary response 88 (MyD88)
functions as a critical signaling adaptor protein integrating stimuli from toll-like receptors …

Preferentially expressed antigen in melanoma (PRAME) is a cancer testis antigen (CTA) that
is selectively expressed in certain somatic tissues, predominantly in the testis, and is …

The histopathological diagnosis of melanoma is fraught with potential pitfalls. In the setting
of cutaneous metastatic melanoma, it is important to recognise the various histological …

Purpose: Uveal melanoma (UM) is a rare disease with a high mortality, and new therapeutic
options are being investigated. Preferentially Expressed Antigen in Melanoma (PRAME) is a …

Despite significant progress in targeted therapy for acute myeloid leukemia (AML), clinical
outcomes are disappointing for elderly patients, patients with less fit disease characteristics …

Immune therapies represented by immune checkpoint blockade (ICB) have significantly
transformed cancer treatment. However, the effectiveness of these treatments depends on …