PI3Ks regulate several key events in the inflammatory response to damage and infection.
There are four Class I PI3K isoforms (PI3Kα, β, γ, δ), three Class II PI3K isoforms (PI3KC2α …

Vimentin, a major constituent of the intermediate filament family of proteins, is ubiquitously
expressed in normal mesenchymal cells and is known to maintain cellular integrity and …

Intermediate filaments (IFs) are one of the three major elements of the cytoskeleton. Their
stability, intrinsic mechanical properties, and cell type–specific expression patterns …

Vimentin is used widely as a marker of the epithelial to mesenchymal transitions (EMTs) that
take place during embryogenesis and metastasis, yet the functional implications of the …

There is an accumulation of evidence in the literature demonstrating the integral role of
vimentin intermediate filaments (IFs) in the progression of lung cancers. Vimentin IF proteins …

Phosphoinositide 3-kinase (PI3K) signaling contributes to a variety of processes, mediating
many aspects of cellular function, including nutrient uptake, anabolic reactions, cell growth …

Vimentin intermediate filaments (VIF) extend throughout the rear and perinuclear regions of
migrating fibroblasts, but only nonfilamentous vimentin particles are present in lamellipodial …

Background Vimentin is a ubiquitous mesenchymal intermediate filament supporting
mechano-structural integrity of quiescent cells while participating in adhesion, migration …

Intermediate filaments (IFs) comprise a diverse group of flexible cytoskeletal structures, the
assembly, dynamics, and functions of which are regulated by posttranslational modifications …

MicroRNAs are post-transcriptional mediators of gene expression and regulation, which play
influential roles in tumorigenesis and cancer metastasis. The expression of tumor …