Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

Tumor-derived extracellular vesicle (TEV) protein biomarkers facilitate cancer diagnosis and
prognostic evaluations. However, the lack of reliable and convenient quantitative methods …

The human dopamine transporter gene SLC6A3 has been consistently implicated in several
neuropsychiatric diseases but the disease mechanism remains elusive. In this risk synthesis …

Dendrocalamus latiflorus Munro is a woody clumping bamboo with rapid shoot growth. Both
genetic transformation and clustered regularly interspaced short palindromic repeats …

The off-target activity of the CRISPR-associated nuclease Cas9 is a potential concern for
therapeutic genome editing applications. Although high-fidelity Cas9 variants have been …

Gene therapy is emerging as a powerful tool to modulate abnormal gene expression, a
hallmark of most CNS disorders. The transformative potentials of recently approved gene …

Background Epigenome editing refers to the targeted reprogramming of genomic loci using
an EpiEditor which may consist of an sgRNA/dCas9 complex that recruits DNMT3A/3L to the …

Johne's disease (JD), also known as paratuberculosis, is a severe production-limiting
disease with significant economic and welfare implications for the global cattle industry …

Epigenetic aging (EA) indices are frequently used as predictors of mortality and other
important health outcomes. However, each of the commonly used array-based indices has …

Conventional methods for detecting single nucleotide polymorphisms (SNPs) in clinical
practice often require substantial time, labor, and specialized equipment, limiting their …