Background Anticholinergics are medications that block the action of acetylcholine in the
central or peripheral nervous system. Medications with anticholinergic properties are …

Objective To evaluate the association between recently raised anticholinergic burden and
risk of acute cardiovascular events in older adults. Design Case-case-time-control study (ie …

Polypharmacy (PP) use is very common in older people and may lead to drug-drug
interactions (DDIs) and anticholinergic burden (ACB) that may affect cognitive function. We …

Background Recent studies have shown that anticholinergic medications are associated
with cardiovascular disease. Little is known about how discontinuation of anticholinergic …

Polypharmacy (use of≥ 5 concurrent medications) is highly prevalent among older adults to
manage chronic diseases and is linked to adverse geriatric outcomes, including physical …

In 1959, Dr. John Apley first published the book, The Child with Abdominal Pains, and
described what he called “little bellyachers”. We now know these conditions as functional …

Background A growing body of research supports the negative impact of anticholinergic
drug burden on physical frailty. However, prior research has been limited to homogeneous …

Confidential: For Review Only Page 1 Confidential: For Review Only Association between
recently elevated anticholinergic burden and risk of acute cardiovascular events: A nationwide …

Objective: To estimate the extent to which comorbidity, polypharmacy, and anticholinergic/
sedative burden interrelate to influence cognitive ability, perceived cognitive deficits and …

Observational studies have shown an association between the use of anticholinergic drugs
and various negative health outcomes. However, when studying cognitive outcomes, there …