Inflammation and aging: signaling pathways and intervention therapies

X Li, C Li, W Zhang, Y Wang, P Qian… - Signal Transduction and …, 2023 - nature.com
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Immunosenescence, aging and successful aging

Y Wang, C Dong, Y Han, Z Gu, C Sun - Frontiers in immunology, 2022 - frontiersin.org
Aging induces a series of immune related changes, which is called immunosenescence,
playing important roles in many age-related diseases, especially neurodegenerative …

[HTML][HTML] Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes

R Karki, BR Sharma, S Tuladhar, EP Williams… - Cell, 2021 - cell.com
COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute
lung damage associated with patient mortality. While multiple inflammatory cytokines are …

[HTML][HTML] Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

DS Simpson, J Pang, A Weir, IY Kong, M Fritsch… - Immunity, 2022 - cell.com
Cell death plays an important role during pathogen infections. Here, we report that interferon-
γ (IFNγ) sensitizes macrophages to Toll-like receptor (TLR)-induced death that requires …

A Gas/phototheranostic Nanocomposite Integrates NIR‐II‐Peak Absorbing Aza‐BODIPY with Thermal‐Sensitive Nitric Oxide Donor for Atraumatic Osteosarcoma …

Z Fang, J Zhang, Z Shi, L Wang, Y Liu… - Advanced …, 2023 - Wiley Online Library
Photothermal therapy (PTT) has received increasing interest in cancer therapeutics owing to
its excellent efficacy and controllability. However, there are two major limitations in PTT …

iNOS as a metabolic enzyme under stress conditions

S Anavi, O Tirosh - Free Radical Biology and Medicine, 2020 - Elsevier
Nitric oxide (NO) is a free radical acting as a cellular signaling molecule in many different
biochemical processes. NO is synthesized from l-arginine through the action of the nitric …

Bioinorganics and wound healing

B Dalisson, J Barralet - Advanced Healthcare Materials, 2019 - Wiley Online Library
Wound dressings and the healing enhancement (increasing healing speed and quality) are
two components of wound care that lead to a proper healing. Wound care today consists …

Inhibition of neutrophil extracellular trap formation alleviates vascular dysfunction in type 1 diabetic mice

C Liu, S Yalavarthi, A Tambralli, L Zeng… - Science …, 2023 - science.org
While neutrophil extracellular traps (NETs) have previously been linked to some diabetes-
associated complications, such as dysfunctional wound healing, their potential role in …

[HTML][HTML] Glycolysis dependent lactate formation in neutrophils: A metabolic link between NOX-dependent and independent NETosis

D Awasthi, S Nagarkoti, S Sadaf, T Chandra… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Neutrophil extracellular traps (NETs) play a pivotal role in the innate immune defense, as
well as in the pathophysiology of various inflammatory disease conditions. Two major types …

Curcumin-incorporated 3D bioprinting gelatin methacryloyl hydrogel reduces reactive oxygen species-induced adipose-derived stem cell apoptosis and improves …

S Xia, T Weng, R Jin, M Yang, M Yu, W Zhang… - Burns & …, 2022 - academic.oup.com
Abstract Background Gelatin methacryloyl (GelMA) hydrogels loaded with stem cells have
proved to be an effective clinical treatment for wound healing. Advanced glycation end …