The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value
The aryl hydrocarbon receptor (AhR) is well-known for its major contributions to the cellular
responses against environmental toxins and carcinogens. Notably, AhR has also emerged …
responses against environmental toxins and carcinogens. Notably, AhR has also emerged …
[HTML][HTML] Genetic susceptibility in childhood acute leukaemias: a systematic review
GD Brisson, LR Alves… - …, 2015 - ncbi.nlm.nih.gov
Acute leukaemias (AL) correspond to 25–35% of all cancer cases in children. The aetiology
is still sheltered, although several factors are implicated in causality of AL subtypes …
is still sheltered, although several factors are implicated in causality of AL subtypes …
Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence
Background Heroin dependence is a debilitating psychiatric disorder with complex
inheritance. Since the dopaminergic system has a key role in rewarding mechanism of the …
inheritance. Since the dopaminergic system has a key role in rewarding mechanism of the …
Pharmacogenetic analysis of high-dose methotrexate treatment in children with osteosarcoma
Inter-individual differences in toxic symptoms and pharmacokinetics of high-dose
methotrexate (MTX) treatment may be caused by genetic variants in the MTX pathway …
methotrexate (MTX) treatment may be caused by genetic variants in the MTX pathway …
Is there etiologic heterogeneity between subtypes of childhood acute lymphoblastic leukemia? A review of variation in risk by subtype
Although substantial advances in the identification of cytogenomic subtypes of childhood
acute lymphoblastic leukemia (ALL) have been made in recent decades, epidemiologic …
acute lymphoblastic leukemia (ALL) have been made in recent decades, epidemiologic …
Genetic susceptibility in childhood acute lymphoblastic leukemia
A Gutierrez-Camino, I Martin-Guerrero, A García-Orad - Medical Oncology, 2017 - Springer
Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and a
leading cause of death due to disease in children. The genetic basis of ALL susceptibility …
leading cause of death due to disease in children. The genetic basis of ALL susceptibility …
The role of ARID5B in acute lymphoblastic leukemia and beyond
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children with distinct
characteristics among different subtypes. Although the etiology of ALL has not been fully …
characteristics among different subtypes. Although the etiology of ALL has not been fully …
[HTML][HTML] HLA-DRB1* 07: 01–HLA-DQA1* 02: 01–HLA-DQB1* 02: 02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic …
N Kutszegi, X Yang, A Gézsi, G Schermann… - …, 2017 - ncbi.nlm.nih.gov
Hypersensitivity reactions are the most frequent dose-limiting adverse reactions to
Escherichia coli-derived asparaginase in pediatric acute lymphoblastic leukemia (ALL) …
Escherichia coli-derived asparaginase in pediatric acute lymphoblastic leukemia (ALL) …
Roles of genetic polymorphisms in the folate pathway in childhood acute lymphoblastic leukemia evaluated by Bayesian relevance and effect size analysis
In this study we investigated whether polymorphisms in the folate pathway influenced the
risk of childhood acute lymphoblastic leukemia (ALL) or the survival rate of the patients. For …
risk of childhood acute lymphoblastic leukemia (ALL) or the survival rate of the patients. For …
Associations of novel genetic variations in the folate‐related and ARID5B genes with the pharmacokinetics and toxicity of high‐dose methotrexate in paediatric acute …
K Csordas, O Lautner‐Csorba… - British journal of …, 2014 - Wiley Online Library
High‐dose methotrexate (HD‐MTX) plays an important role in the consolidation therapy of
acute lymphoblastic leukaemia (ALL) in many treatment regimens worldwide. However …
acute lymphoblastic leukaemia (ALL) in many treatment regimens worldwide. However …