The discovery and implementation of antibiotics in the early twentieth century transformed
human health and wellbeing. Chemical synthesis enabled the development of the first …

Lipid II is a membrane-anchored cell-wall precursor that is essential for bacterial cell-wall
biosynthesis. The effectiveness of targeting Lipid II as an antibacterial strategy is highlighted …

Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

This review covers some of the recent progress in the field of peptide antibiotics with a focus
on compounds with novel or established mode of action and with demonstrated efficacy in …

Ever since the world‐shaping discovery of penicillin, nature's molecular diversity has been
extensively screened for new medications and lead compounds in drug discovery. The …

Covering: up to 2017 History points to the bacterial cell wall biosynthetic network as a very
effective target for antibiotic intervention, and numerous natural product inhibitors have been …

Cyclic lipopeptides (CLPs) are a promising class of natural products with antibiotic
properties. CLPs are amphiphilic molecules, composed of a fatty acid tail linked to a short …

The lipoglycodepsipeptide antibiotic ramoplanin is proposed to inhibit bacterial cell wall
biosynthesis by binding to intermediates along the pathway to mature peptidoglycan, which …

An ortho-selective ammonium chloride salt-catalyzed direct C–H monohalogenation of
phenols and 1, 1′-bi-2-naphthol (BINOL) with 1, 3-dichloro-5, 5-dimethylhydantoin …

Before the introduction of antibiotics in the 1940s and 1950s, patients with
bacteremiasbacteria in the blood streamshad almost no chance of survival. 1, 2 Antibiotics …