Developing Aspergillus as a host for heterologous expression

D Lubertozzi, JD Keasling - Biotechnology advances, 2009 - Elsevier
Filamentous fungi have long been used for production of a range of valuable products; with
the advent of molecular biology, it became apparent that these fungi possess considerable …

Organic acids: old metabolites, new themes

I Goldberg, JS Rokem, O Pines - Journal of Chemical …, 2006 - Wiley Online Library
Fumaric, l‐malic and citric acids are intermediates of the oxidative tricarboxylic acid (TCA)
cycle which in eukaryotes is localized in mitochondria. These organic acids are synthesized …

Sustainable carbon sources for microbial organic acid production with filamentous fungi

S Dörsam, J Fesseler, O Gorte, T Hahn, S Zibek… - Biotechnology for …, 2017 - Springer
Background The organic acid producer Aspergillus oryzae and Rhizopus delemar are able
to convert several alternative carbon sources to malic and fumaric acid. Thus, carbohydrate …

Biochemical systems theory: a review

EO Voit - International Scholarly Research Notices, 2013 - Wiley Online Library
Biochemical systems theory (BST) is the foundation for a set of analytical andmodeling tools
that facilitate the analysis of dynamic biological systems. This paper depicts major …

Morphology and productivity of filamentous fungi

LH Grimm, S Kelly, R Krull, DC Hempel - Applied microbiology and …, 2005 - Springer
Cultivation processes involving filamentous fungi have been optimised for decades to obtain
high product yields. Several bulk chemicals like citric acid and penicillin are produced this …

Expression and export: recombinant protein production systems for Aspergillus

A Fleißner, P Dersch - Applied microbiology and biotechnology, 2010 - Springer
Several Aspergillus species, in particular Aspergillus niger and Aspergillus oryzae, are
widely used as protein production hosts in various biotechnological applications. In order to …

Leaching of copper, nickel and cobalt from Indian Ocean manganese nodules by Aspergillus niger

KD Mehta, C Das, BD Pandey - Hydrometallurgy, 2010 - Elsevier
The leaching of copper, nickel and cobalt from polymetallic manganese nodules from the
Indian Ocean was investigated using a fungus—Aspergillus niger. Parameters such as initial …

Engineering of primary carbon metabolism in filamentous fungi

T Chroumpi, MR Mäkelä, RP de Vries - Biotechnology advances, 2020 - Elsevier
Filamentous fungi are important industrial cell factories used for the production of a wide
range of enzymes and metabolites. Their primary metabolism is a significant source of …

Reconstruction of the central carbon metabolism of Aspergillus niger

H David, M Åkesson, J Nielsen - European Journal of …, 2003 - Wiley Online Library
The topology of central carbon metabolism of Aspergillus niger was identified and the
metabolic network reconstructed, by integrating genomic, biochemical and physiological …

Enhanced citrate production through gene insertion in Aspergillus niger

WA De Jongh, J Nielsen - Metabolic engineering, 2008 - Elsevier
The effect of inserting genes involved in the reductive branch of the tricarboxylic acid (TCA)
cycle on citrate production by Aspergillus niger was evaluated. Several different genes were …