[HTML][HTML] Artificial intelligence for COVID-19 drug discovery and vaccine development

A Keshavarzi Arshadi, J Webb, M Salem… - Frontiers in Artificial …, 2020 - frontiersin.org
SARS-COV-2 has roused the scientific community with a call to action to combat the growing
pandemic. At the time of this writing, there are as yet no novel antiviral agents or approved …

Promising role of defensins peptides as therapeutics to combat against viral infection

SS Solanki, P Singh, P Kashyap, MS Sansi… - Microbial pathogenesis, 2021 - Elsevier
Antimicrobial peptides (AMPs) are ubiquitously present small peptides, which play a critical
function in the innate immune system. The defensin class of AMPs represented an …

[HTML][HTML] Catechin and curcumin interact with S protein of SARS-CoV2 and ACE2 of human cell membrane: insights from computational studies

AB Jena, N Kanungo, V Nayak, GBN Chainy… - Scientific reports, 2021 - nature.com
The recent outbreak of the coronavirus (SARS-CoV2) is an unprecedented threat to human
health and society across the globe. In this context, development of suitable interventions is …

[HTML][HTML] In silico discovery of candidate drugs against Covid-19

C Cava, G Bertoli, I Castiglioni - Viruses, 2020 - mdpi.com
Previous studies reported that Angiotensin converting enzyme 2 (ACE2) is the main cell
receptor of SARS-CoV and SARS-CoV-2. It plays a key role in the access of the virus into the …

The discovery of a putative allosteric site in the SARS-CoV-2 spike protein using an integrated structural/dynamic approach

L Di Paola, H Hadi-Alijanvand, X Song… - Journal of proteome …, 2020 - ACS Publications
SARS-CoV-2 has caused the largest pandemic of the twenty-first century (COVID-19),
threatening the life and economy of all countries in the world. The identification of novel …

[HTML][HTML] Toxin-like peptides from the bacterial cultures derived from gut microbiome infected by SARS-CoV-2—new data for a possible role in the long COVID pattern

C Brogna, S Cristoni, B Brogna, DR Bisaccia, G Marino… - Biomedicines, 2022 - mdpi.com
It has been 3 years since the beginning of the SARS-CoV-2 outbreak, however it is as yet
little known how to care for the acute COVID-19 and long COVID patients. COVID-19 clinical …

[HTML][HTML] Ramping up antimicrobial peptides against severe acute respiratory syndrome coronavirus-2

SK Ghosh, A Weinberg - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Human-derived antimicrobial peptides (AMPs), such as defensins and cathelicidin LL-37,
are members of the innate immune system and play a crucial role in early pulmonary …

[HTML][HTML] In silico discovery of antimicrobial peptides as an alternative to control SARS-CoV-2

Y Liscano, J Oñate-Garzón, ID Ocampo-Ibáñez - Molecules, 2020 - mdpi.com
A serious pandemic has been caused by the severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2). The interaction between spike surface viral protein (Sgp) and the …

[HTML][HTML] Antimicrobial peptides and physical activity: a great hope against COVID 19

S Laneri, M Brancaccio, C Mennitti, MG De Biasi… - Microorganisms, 2021 - mdpi.com
Antimicrobial peptides (AMPs), α-and β-defensins, possess antiviral properties. These AMPs
achieve viral inhibition through different mechanisms of action. For example, they can:(i) …

Identifying anti-coronavirus peptides by incorporating different negative datasets and imbalanced learning strategies

Y Pang, Z Wang, JH Jhong, TY Lee - Briefings in bioinformatics, 2021 - academic.oup.com
As the current worldwide outbreaks of the SARS-CoV-2, it is urgently needed to develop
effective therapeutic agents for inhibiting the pathogens or treating the related diseases …