For all microorganisms, acquisition of metal ions is essential for survival in the environment
or in their infected host. Metal ions are required in many biological processes as …

Iron is a transition metal utilized by nearly all forms of life for essential cellular processes,
such as DNA synthesis and cellular respiration. During infection by bacterial pathogens, the …

Highlights•HmuUV is the first structure of a heme uptake inner membrane ABC
transporter.•A novel assay was developed to assess in vitro heme uptake for …

Iron is essential for the survival of most bacteria but presents a significant challenge given its
limited bioavailability. Furthermore, the toxicity of iron combined with the need to maintain …

Active nutrient uptake is fundamental for survival and pathogenicity of Gram-negative
bacteria, which operate a multi-protein Ton system to transport essential nutrients like metals …

The Ton complex is a molecular motor that uses the proton gradient at the inner membrane
of Gram-negative bacteria to generate force and movement, which are transmitted to …

Heme is an indispensable cofactor for almost all aerobic life, including the human host and
many bacterial pathogens. During infection, heme and hemoproteins are the largest source …

Intervening protein sequences (inteins) from extremely halophilic haloarchaea can be
inactive under low salinity but could be activated by increasing the salt content to a specific …

Background Heme is an important nutritional iron source for almost all bacteria. Elevated
heme concentrations, in contrast, are toxic eg due to the generation of reactive oxygen …

Iron is an essential micronutrient for all bacteria but presents a significant challenge given its
limited bioavailability. Furthermore, iron's toxicity combined with the need to maintain iron …