Epilepsy—definition, classification, pathophysiology, and epidemiology

J Falco-Walter - Seminars in neurology, 2020 - thieme-connect.com
Seizures affect the lives of 10% of the global population and result in epilepsy in 1 to 2% of
people around the world. Current knowledge about etiology, diagnosis, and treatments for …

Hypertension: do inflammation and immunity hold the key to solving this epidemic?

MS Madhur, F Elijovich, MR Alexander, A Pitzer… - Circulation …, 2021 - Am Heart Assoc
Elevated cardiovascular risk including stroke, heart failure, and heart attack is present even
after normalization of blood pressure in patients with hypertension. Underlying immune cell …

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

VL Feigin, E Nichols, T Alam, MS Bannick… - The Lancet …, 2019 - thelancet.com
Background Neurological disorders are increasingly recognised as major causes of death
and disability worldwide. The aim of this analysis from the Global Burden of Diseases …

Critical review of transcutaneous vagus nerve stimulation: challenges for translation to clinical practice

JYY Yap, C Keatch, E Lambert, W Woods… - Frontiers in …, 2020 - frontiersin.org
Several studies have illustrated that transcutaneous vagus nerve stimulation (tVNS) can
elicit therapeutic effects that are similar to those produced by its invasive counterpart, vagus …

Epilepsy in older people

A Sen, N Jette, M Husain, JW Sander - The Lancet, 2020 - thelancet.com
Globally, as populations age there will be challenges and opportunities to deliver optimal
health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent …

[HTML][HTML] Brain concentrations of glutamate and GABA in human epilepsy: A review

GL Sarlo, KF Holton - Seizure, 2021 - Elsevier
An imbalance between excitation and inhibition has been a longstanding proposed
mechanism regarding ictogenesis and epileptogenesis. This imbalance is related to …

Epilepsy in China: major progress in the past two decades

D Ding, D Zhou, JW Sander, W Wang, S Li… - The Lancet …, 2021 - thelancet.com
China has approximately 10 million people with epilepsy. There is a vast epilepsy treatment
gap in China, mainly driven by deficiencies in health-care delivery and social discrimination …

Ketogenic diet and epilepsy

M Ułamek-Kozioł, SJ Czuczwar, S Januszewski… - Nutrients, 2019 - mdpi.com
Currently available pharmacological treatment of epilepsy has limited effectiveness. In
epileptic patients, pharmacological treatment with available anticonvulsants leads to seizure …

Personalised virtual brain models in epilepsy

V Jirsa, H Wang, P Triebkorn, M Hashemi… - The Lancet …, 2023 - thelancet.com
Individuals with drug-resistant focal epilepsy are candidates for surgical treatment as a
curative option. Before surgery can take place, the patient must have a presurgical …

Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus

RJ Burman, RE Rosch, JM Wilmshurst, A Sen… - Nature Reviews …, 2022 - nature.com
Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …