The increasing population will challenge healthcare, particularly because the worldwide
population has never been older. Therapeutic solutions to age-related disease will be …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is an evolutionarily
conserved protein kinase and the most studied member of the Dual-specificity tyrosine …

Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). DS is a gene
dosage disorder that results in multiple phenotypes including congenital heart defects. This …

Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases
(CLKs) recently attracted attention due to their central involvement in various pathologies …

Patients with Down syndrome (DS), or trisomy 21 (T21), are at increased risk of transient
abnormal myelopoiesis (TAM) and acute megakaryoblastic leukemia (ML-DS). Both TAM …

Cellular senescence is a dynamic stress response process that contributes to aging. From
initiation to maintenance, senescent cells continuously undergo complex molecular changes …

Diabetes results from an inadequate number of insulin-producing human beta cells. There is
currently no clinically available effective means to restore beta cell mass in millions of …

Cancer is a leading cause of disease-related mortality worldwide. Drug resistance is one of
the primary reasons for the failure of anticancer therapy. There are a number of underlying …

Cell proliferation control is essential during development and for maintaining adult tissues.
Loss of that control promotes not only oncogenesis when cells proliferate inappropriately but …

Diabetes is characterized by variable loss of insulin-producing beta cells, and new
regenerative approaches to increasing the functional beta cell mass of patients hold promise …