BMP signaling plays an important role in dentin development. BMPs and antagonists
regulate odontoblast differentiation and downstream gene expression via canonical Smad …

Congenitally missing teeth (CMT), or as usually called hypodontia, is a highly prevalent and
costly dental anomaly. Besides an unfavorable appearance, patients with missing teeth may …

The Msx1 homeobox gene is expressed at diverse sites of epithelial–mesenchymal
interaction during vertebrate embryogenesis, and has been implicated in signalling …

We demonstrate that a mutation in the homeobox gene, MSX1, causes a common
developmental anomaly, familial tooth agenesis. Genetic linkage analyses in a family with …

Lymphoid enhancer factor 1 (LEF-1) is a sequence-specific DNA-binding protein that is
expressed in pre-B and T lymphocytes of adult mice, and in the neural crest …

Growth factor-mediated signaling has been implicated in the regulation of epithelial-
mesenchymal interactions during organogenesls. Bone morphogenetic protein 4 (BMP-4), a …

Dental agenesis is the most common developmental anomaly in humans and is frequently
associated with several other oral abnormalities. Whereas the incidence of missing teeth …

Craniosynostosis, the premature fusion of calvarial sutures, is a common developmental
anomaly that causes abnormal skull shape. The locus for one autosomal dominant form of …

Background Fibroblasts are the predominant cells of the periodontal ligament (PL) and have
important roles in the development, function, and regeneration of the tooth support …

Bone morphogenetic proteins (BMPs) are morphogenetic signaling molecules essential for
embryonic patterning. To obtain molecular insight into the influence of BMPs on …