5-Fluorouracil nano-delivery systems as a cutting-edge for cancer therapy

AA Valencia-Lazcano, D Hassan, M Pourmadadi… - European Journal of …, 2023 - Elsevier
Fluorouracil (5-FU) is amongst the most commonly used antimetabolite chemotherapeutic
agents in recent decades. However, its low bioavailability, short half-life, rapid metabolism …

Replacement, reduction, and refinement of animal experiments in anticancer drug development: the contribution of 3D in vitro cancer models in the drug efficacy …

EM Tosca, D Ronchi, D Facciolo, P Magni - Biomedicines, 2023 - mdpi.com
In the last decades three-dimensional (3D) in vitro cancer models have been proposed as a
bridge between bidimensional (2D) cell cultures and in vivo animal models, the gold …

A Holistic Approach to Hard-to-Treat Cancers: The Future of Immunotherapy for Glioblastoma, Triple Negative Breast Cancer, and Advanced Prostate Cancer

C Puig-Saenz, JRD Pearson, JE Thomas, SEB McArdle - Biomedicines, 2023 - mdpi.com
Immunotherapy represents an attractive avenue for cancer therapy due to its tumour
specificity and relatively low frequency of adverse effects compared to other treatment …

Cytotoxic and anti-metastatic effects of Hypericum perforatum olive oil extract in colorectal cancer cells and human bone marrow derived stem cells

H Yildirim, BE Daşkan - Natural Product Research, 2024 - Taylor & Francis
This study is aimed to investigate the effects of Hypericum perforatum olive oil extract on the
cytotoxic and metastatic properties of human colorectal cancer cells and human bone …

[HTML][HTML] Role of Aldehyde Dehydrogenase 3A1 in Cancer Progression

S Lee, J Jung - Drug Targets and Therapeutics, 2022 - journal-dtt.org
Aldehyde dehydrogenase (ALDH) catalyzes the oxidation of aldehydes and is well known to
detoxify exogenous and endogenous aldehydes. ALDH has also been reported to be …