UPLC versus HPLC on drug analysis: advantageous, applications and their validation parameters

M Gumustas, S Kurbanoglu, B Uslu, SA Ozkan - Chromatographia, 2013 - Springer
Liquid chromatography (LC) is a separation technique used in many different areas to aid
the identification and quantification of substances in various matrices. LC techniques with …

Forced degradation and impurity profiling: recent trends in analytical perspectives

D Jain, PK Basniwal - Journal of pharmaceutical and biomedical analysis, 2013 - Elsevier
This review describes an epigrammatic impression of the recent trends in analytical
perspectives of degradation and impurities profiling of pharmaceuticals including active …

Critical analytical review: Rare and recent applications of refractive index detector in HPLC chromatographic drug analysis

MM Al-Sanea, M Gamal - Microchemical Journal, 2022 - Elsevier
In this review article, the first collection of drugs analyzed through high-performance liquid
chromatography coupled with a refractive index detector (HPLC-RI) was discussed. The list …

Review on pharmaceutical impurities, stability studies and degradation products: an analytical approach

ZA Alothman, N Rahman… - Reviews in Advanced …, 2013 - ingentaconnect.com
The development of the pharmaceuticals brought a revolution in human health. These
pharmaceuticals would serve their intended only if they are free from the impurities and are …

Development of HPLC-CAD method for simultaneous quantification of nine related substances in ursodeoxycholic acid and identification of two unknown impurities by …

Y Huang, H Lu, Z Li, Y Zeng, Q Xu, Y Wu - Journal of pharmaceutical and …, 2023 - Elsevier
Ursodeoxycholic acid has gained increasing attention due to its recent discovery of the
preventive effect on SARS-CoV-2 infection. Ursodeoxycholic acid has been included in …

Hyphenating temperature gradient elution with refractive index detection through temperature-responsive liquid chromatography

E Bandini, K Wicht, A Ampe, M Baert, H Eghbali… - Analytica Chimica …, 2022 - Elsevier
Refractive index detection (RID) is attractive because it allows approaching the benefits of
universal detection with liquid chromatography, by which ideally standard independent …

Assessing mass balance in pharmaceutical drug products: New insights into an old topic

SW Baertschi, BW Pack, CSH Hyzer… - TrAC Trends in Analytical …, 2013 - Elsevier
Mass balance is an important concept in pharmaceutical development, but it often proves
challenging to assess accurately. This article explores the various methods by which mass …

Study of quality and stability of ursodeoxycholic acid formulations for oral pediatric administration

A Santoveña, E Sánchez-Negrín, L Charola… - International Journal of …, 2014 - Elsevier
This paper describes a rational method of characterizing the biopharmaceutical stability of
two oral suspensions of ursodeoxycholic acid (UDCA) used in pediatrics. Because there is …

微流蒸发光散射检测器与毛细管液相色谱的联用及其在银杏叶提取物分析中的应用

赵卉, 王玉红, 刘芳, 王彦, 谷雪, 阎超 - 色谱, 2013 - chrom-china.com
将微流蒸发光散射检测器(μELSD) 与毛细管液相色谱(cLC) 联用, 应用于中药银杏叶提取物及其
分散片制剂的分离检测领域. 首先对μELSD 仪器参数进行优化. 通过调节漂移管温度与载气流量 …

Validated spectrophotometric and RP-HPLC–DAD methods for the determination of ursodeoxycholic acid based on derivatization with 2-nitrophenylhydrazine

DS El-Kafrawy, TS Belal, MS Mahrous… - Journal of AOAC …, 2017 - academic.oup.com
This work describes the development, validation, and application of two simple, accurate,
and reliable methods for the determination of ursodeoxycholic acid (UDCA) in bulk powder …