Rodent models of attention-deficit hyperactivity disorder: An updated framework for model validation and therapeutic drug discovery
KM Kantak - Pharmacology Biochemistry and Behavior, 2022 - Elsevier
There are over twenty rodent models of Attention-Deficit Hyperactivity Disorder (ADHD), with
most reflecting a recognized ADHD subtype. Of these, only five rat models (Neonatal 6 …
most reflecting a recognized ADHD subtype. Of these, only five rat models (Neonatal 6 …
The stomach-derived hormone ghrelin increases impulsive behavior
RH Anderberg, C Hansson, M Fenander… - …, 2016 - nature.com
Impulsivity, defined as impaired decision making, is associated with many psychiatric and
behavioral disorders, such as attention-deficit/hyperactivity disorder as well as eating …
behavioral disorders, such as attention-deficit/hyperactivity disorder as well as eating …
DAT1 methylation is associated with methylphenidate response on oppositional and hyperactive-impulsive symptoms in children and adolescents with ADHD
K Ding, J Yang, GP Reynolds, B Chen… - The World Journal of …, 2017 - Taylor & Francis
Objectives: To examine the association of the DNA methylation of DAT1 and DRD4 gene
with methylphenidate (MPH) response in attention deficit hyperactivity disorder (ADHD) …
with methylphenidate (MPH) response in attention deficit hyperactivity disorder (ADHD) …
Cross‐species translational paradigms for assessing positive valence system as defined by the RDoC matrix
TD Dexter, BZ Roberts, SM Ayoub… - Journal of …, 2024 - Wiley Online Library
Functions associated with processing reward‐related information are fundamental drivers of
motivation, learning, and goal‐directed behavior. Such functions have been classified as the …
motivation, learning, and goal‐directed behavior. Such functions have been classified as the …
The developmental inter‐relationships between activity, novelty preferences, and delay discounting in male and female rats
Increased locomotion, novelty‐seeking, and impulsivity are risk factors associated with
substance use. In this study, the inter‐relationships between activity, novelty preferences …
substance use. In this study, the inter‐relationships between activity, novelty preferences …
Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity
Impulsive choice has enduring trait-like characteristics and is defined by preference for small
immediate rewards over larger delayed ones. Importantly, it is a determining factor in the …
immediate rewards over larger delayed ones. Importantly, it is a determining factor in the …
Emotional, behavioral, and cognitive correlates of attention deficit and hyperactive disorder (ADHD) screening and diagnosis history: sex/gender differences
S Assari - Journal of neurology & neuromedicine, 2021 - jneurology.com
Background: While clinical studies have documented sex differences in emotional,
behavioral, and cognitive function of children with Attention Deficit and Hyperactive Disorder …
behavioral, and cognitive function of children with Attention Deficit and Hyperactive Disorder …
Juvenile exposure to methylphenidate and guanfacine in rats: effects on early delay discounting and later cocaine-taking behavior
Rationale Both methylphenidate (MPH), a catecholamine reuptake blocker, and guanfacine,
an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD) …
an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD) …
Attentional performance, impulsivity, and related neurotransmitter systems in apoE2, apoE3, and apoE4 female transgenic mice
I Reverte, F Peris-Sampedro, P Basaure, L Campa… - …, 2016 - Springer
Abstract Rationale The apolipoprotein E (apoE) genotype influences cognitive performance
in humans depending on age and sex. While the detrimental role of the apoE4 isoform on …
in humans depending on age and sex. While the detrimental role of the apoE4 isoform on …
Preventative treatment in an animal model of ADHD: behavioral and biochemical effects of methylphenidate and its interactions with ovarian hormones in female rats
Clinical and preclinical studies on attention deficit hyperactivity disorder (ADHD) show that
juvenile males that are exposed to methylphenidate (MPH) show reduced risk for substance …
juvenile males that are exposed to methylphenidate (MPH) show reduced risk for substance …