A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease
The Huntington's disease mutation is a CAG repeat expansion in the huntingtin gene that
results in an expanded polyglutamine tract in the huntingtin protein. The CAG repeat is …
results in an expanded polyglutamine tract in the huntingtin protein. The CAG repeat is …
Glutamine missense suppressor transfer RNAs inhibit polyglutamine aggregation
Huntington's disease (HD) is caused by polyglutamine (polyQ) repeat expansions in the
huntingtin gene. HD-causative polyQ alleles lead to protein aggregation, which is a …
huntingtin gene. HD-causative polyQ alleles lead to protein aggregation, which is a …
Suppression of Huntington's Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding
Huntington's disease (HD) arises from a CAG expansion in the huntingtin (HTT) gene
beyond a critical threshold. A major thrust of current HD therapeutic development is lowering …
beyond a critical threshold. A major thrust of current HD therapeutic development is lowering …
Using gene or cell therapies to treat Huntington's disease
CS Binda, MJ Lelos, AE Rosser, TH Massey - Handbook of Clinical …, 2024 - Elsevier
Huntington's disease is caused by a CAG repeat expansion in the first exon of the HTT gene,
leading to the production of gain-of-toxic-function mutant huntingtin protein species and …
leading to the production of gain-of-toxic-function mutant huntingtin protein species and …
Positron emission tomography (PET) imaging biomarkers in Huntington's disease
L Everix, S Staelens, D Bertoglio - Biomarkers for Huntington's Disease …, 2023 - Springer
Huntington's disease (HD) is a rare, autosomal, and dominantly inherited
neurodegenerative disease characterized by aggregation of mutated Huntingtin protein …
neurodegenerative disease characterized by aggregation of mutated Huntingtin protein …
[HTML][HTML] Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease
G Birolini, M Valenza, I Ottonelli, F Talpo… - Pharmacological …, 2023 - Elsevier
Evidence that Huntington's disease (HD) is characterized by impaired cholesterol
biosynthesis in the brain has led to strategies to increase its level in the brain of the rapidly …
biosynthesis in the brain has led to strategies to increase its level in the brain of the rapidly …
[HTML][HTML] Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the …
Expansion of a triplet repeat tract in exon 1 of the HTT gene causes Huntington's disease
(HD). The mutant HTT protein (mHTT) has numerous aberrant interactions with diverse …
(HD). The mutant HTT protein (mHTT) has numerous aberrant interactions with diverse …
mTOR inhibition in Q175 Huntington's disease model mice facilitates neuronal autophagy and mutant huntingtin clearance
P Stavrides, CN Goulbourne, J Peddy, C Huo, M Rao… - bioRxiv, 2024 - biorxiv.org
Huntington's disease (HD) is caused by expansion of the polyglutamine stretch in huntingtin
protein (HTT) resulting in hallmark aggresomes/inclusion bodies (IBs) composed of mutant …
protein (HTT) resulting in hallmark aggresomes/inclusion bodies (IBs) composed of mutant …
Intrastriatal delivery of a zinc finger protein targeting the mutant HTT gene obviates lipid phenotypes in zQ175DN HD mice
Reducing the burden of mutant Huntingtin (mHTT) protein in brain cells is a strategy for
treating Huntington's disease (HD). However, it is still unclear what pathological changes …
treating Huntington's disease (HD). However, it is still unclear what pathological changes …
[PDF][PDF] A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's
A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease
Page 1 A CAG repeat threshold for therapeutics targeting somatic instability in Huntington’s …
Page 1 A CAG repeat threshold for therapeutics targeting somatic instability in Huntington’s …