Fish immunization has been carried out for over 50 years and is generally accepted as an
effective method for preventing a wide range of bacterial and viral diseases. Vaccination …

The success of the first licensed mRNA-based vaccines against COVID-19 has created a
widespread interest on mRNA technology for vaccinology. As expected, the number of …

Recombinant nucleic acids are considered as promising next-generation vaccines. These
vaccines express the native antigen upon delivery into tissue, thus mimicking live attenuated …

Alphavirus replicon particle-based vaccine vectors derived from Sindbis virus (SIN), Semliki
Forest virus, and Venezuelan equine encephalitis virus (VEE) have been shown to induce …

Alphaviruses are positive‐stranded RNA viruses that have a broad host range and therefore
are capable of replicating in many vertebrate and invertebrate cells. The single‐stranded …

Replication-competent propagation-deficient virus vectors based on the transmissible
gastroenteritis coronavirus (TGEV) genome that are deficient in the essential E gene have …

We have expressed and characterized the severe acute respiratory syndrome coronavirus
(SARS-CoV) spike protein in cDNA-transfected mammalian cells. The full-length spike …

Successful cancer gene therapy requires a vector that systemically and specifically targets
tumor cells throughout the body. Although several vectors have been developed to express …

The lung is the prophylaxis target against SARS-CoV-2 infection, and neutralizing
antibodies are a leading class of biological products against various infectious viral …

Coronaviruses induce in infected cells the formation of double membrane vesicles, which
are the sites of RNA replication. Not much is known about the formation of these vesicles …