[HTML][HTML] Simulating realistic membrane shapes

W Pezeshkian, SJ Marrink - Current opinion in cell biology, 2021 - Elsevier
Biological membranes exhibit diversity in their shapes and complexity in chemical
compositions that are linked to many cellular functions. These two central features of …

A review of mechanics-based mesoscopic membrane remodeling methods: capturing both the physics and the chemical diversity

G Kumar, SC Duggisetty, A Srivastava - The Journal of Membrane Biology, 2022 - Springer
Specialized classes of proteins, working together in a tightly orchestrated manner, induce
and maintain highly curved cellular and organelles membrane morphology. Due to the …

Reversible membrane deformations by straight DNA origami filaments

HG Franquelim, H Dietz, P Schwille - Soft Matter, 2021 - pubs.rsc.org
Membrane-active cytoskeletal elements, such as FtsZ, septin or actin, form filamentous
polymers able to induce and stabilize curvature on cellular membranes. In order to emulate …

Synthetic membrane shaper for controlled liposome deformation

N De Franceschi, W Pezeshkian, A Fragasso… - ACS …, 2022 - ACS Publications
Shape defines the structure and function of cellular membranes. In cell division, the cell
membrane deforms into a “dumbbell” shape, while organelles such as the autophagosome …

Normal red blood cells' shape stabilized by membrane's in-plane ordering

L Mesarec, W Góźdź, A Iglič, V Kralj-Iglič, EG Virga… - Scientific reports, 2019 - nature.com
Red blood cells (RBCs) are present in almost all vertebrates and their main function is to
transport oxygen to the body tissues. RBCs' shape plays a significant role in their …

Mesoscale simulations: an indispensable approach to understand biomembranes

AL Duncan, W Pezeshkian - Biophysical Journal, 2023 - cell.com
Computer simulation techniques form a versatile tool, a computational microscope, for
exploring biological processes. This tool has been particularly effective in exploring different …

Tubulation and dispersion of oil by bacterial growth on droplets

V Hickl, G Juarez - Soft Matter, 2022 - pubs.rsc.org
Bacteria on surfaces exhibit collective behaviors, such as active turbulence and active
stresses, which result from their motility, growth, and interactions with their local …

A human septin octamer complex sensitive to membrane curvature drives membrane deformation with a specific mesh-like organization

K Nakazawa, G Kumar, B Chauvin… - Journal of Cell …, 2023 - journals.biologists.com
Septins are cytoskeletal proteins interacting with the inner plasma membrane and other
cytoskeletal partners. Being key in membrane remodeling processes, they often localize at …

Close, but not too close: a mesoscopic description of (a) symmetry and membrane shaping mechanisms

VT Ruhoff, PM Bendix… - Emerging Topics in Life …, 2023 - portlandpress.com
Biomembranes are fundamental to our understanding of the cell, the basic building block of
all life. An intriguing aspect of membranes is their ability to assume a variety of shapes …

Membrane remodeling due to a mixture of multiple types of curvature proteins

G Kumar, A Srivastava - Journal of Chemical Theory and …, 2022 - ACS Publications
We present an extension of the Monte Carlo based mesoscopic membrane model, where
the membrane is represented as a dynamically triangulated surface and the proteins are …