The role of engineered materials in mucosal vaccination strategies
Mucosal pathogens, as exemplified by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), human immunodeficiency virus (HIV) and Mycobacterium tuberculosis, lead …
(SARS-CoV-2), human immunodeficiency virus (HIV) and Mycobacterium tuberculosis, lead …
Nasal delivery as a strategy for the prevention and treatment of COVID-19
Introduction The upper respiratory tract is a major route of infection for COVID-19 and other
respiratory diseases. Thus, it appears logical to exploit the nose as administration site to …
respiratory diseases. Thus, it appears logical to exploit the nose as administration site to …
Respiratory delivery of passive immunotherapies for SARS-CoV-2 prophylaxis and therapy
Convalescent plasma has been extensively tested during the COVID-19 pandemic as a
transfusion product. Similarly, monoclonal antibodies have been largely administered either …
transfusion product. Similarly, monoclonal antibodies have been largely administered either …
Blood filtering system for COVID-19 management: novel modality of the cytokine storm therapeutics
The newly emerged coronavirus (SARS-CoV-2) is virulent, contagious, and has rapidly
gained many mutations, which makes it highly infectious and swiftly transmissible around …
gained many mutations, which makes it highly infectious and swiftly transmissible around …
Early intervention with azelastine nasal spray may reduce viral load in SARS-CoV-2 infected patients
JP Klussmann, M Grosheva, P Meiser, C Lehmann… - Scientific Reports, 2023 - nature.com
With the changing epidemiology of COVID-19 and its impact on our daily lives, there is still
an unmet need of COVID-19 therapies treating early infections to prevent progression. The …
an unmet need of COVID-19 therapies treating early infections to prevent progression. The …
[HTML][HTML] Novel strategies in systemic and local administration of therapeutic monoclonal antibodies
M Prašnikar, MB Žiberna, MG Matjaž… - International journal of …, 2024 - Elsevier
Monoclonal antibodies (mAbs) are an evolving class of biopharmaceuticals, with
advancements evident across various stages of their development. While discovery, mAb …
advancements evident across various stages of their development. While discovery, mAb …
[HTML][HTML] Cyclosporine A micellar nasal spray characterization and antiviral action against SARS-CoV-2
F Guareschi, E Del Favero, C Ricci, L Cantù… - European Journal of …, 2024 - Elsevier
The upper airways represent the point of entrance from where Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) infection spreads to the lungs. In the present work …
Syndrome Coronavirus 2 (SARS-CoV-2) infection spreads to the lungs. In the present work …
Spray vaccination with a safe and bivalent H9N2 recombinant chimeric NDV vector vaccine elicits complete protection against NDV and H9N2 AIV challenge
X Wang, J Dai, W Yang, Y Yao, J Zhang, K Liu, X Lu… - Veterinary …, 2025 - Springer
Newcastle disease virus (NDV) and H9N2 avian influenza virus (AIV) represent significant
pathogenic risks to the poultry industry, leading to considerable economic losses …
pathogenic risks to the poultry industry, leading to considerable economic losses …
Discovery of a nasal spray steroid, tixocortol, as an inhibitor of SARS-CoV-2 main protease and viral replication
Coronaviruses rely on the viral-encoded chymotrypsin-like main protease (Mpro or 3CLpro)
for replication and assembly. Our previous research on Mpro of SARS-CoV-2 identified …
for replication and assembly. Our previous research on Mpro of SARS-CoV-2 identified …
Effects of Nozzle Retraction Elimination on Spray Distribution in Middle-Posterior Turbinate Regions: A Comparative Study
The standard multi-dose nasal spray pump features an integrated actuator and nozzle,
which inevitably causes a retraction of the nozzle tip during application. The retraction stroke …
which inevitably causes a retraction of the nozzle tip during application. The retraction stroke …