Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Structural and functional architecture of AMPA-type glutamate receptors and their auxiliary proteins
IH Greger, JF Watson, SG Cull-Candy - Neuron, 2017 - cell.com
AMPA receptors (AMPARs) are tetrameric ion channels that together with other ionotropic
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
glutamate receptors (iGluRs), the NMDA and kainate receptors, mediate a majority of …
Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8
INTRODUCTION Neuronal communication at excitatory synapses in the brain involves
release of the neurotransmitter l-glutamate from the presynapse of one cell and its detection …
release of the neurotransmitter l-glutamate from the presynapse of one cell and its detection …
Comparing plant and animal glutamate receptors: common traits but different fates?
MM Wudick, E Michard… - Journal of …, 2018 - academic.oup.com
Animal ionotropic glutamate receptors (iGluRs) are ligand-gated channels whose evolution
is intimately linked to that of the nervous system, where the agonist glutamate and co …
is intimately linked to that of the nervous system, where the agonist glutamate and co …
α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly
Many neurological disorders show an increased prevalence of GluA2-lacking, Ca 2+-
permeable AMPA receptors (CP-AMPARs), which dramatically alters synaptic function …
permeable AMPA receptors (CP-AMPARs), which dramatically alters synaptic function …
Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human
SX Peng, J Pei, B Rinaldi, J Chen, YH Ge, M Jia… - Molecular …, 2022 - nature.com
Inappropriate aggression in humans hurts the society, families and individuals. The genetic
basis for aggressive behavior, however, remains largely elusive. In this study, we identified …
basis for aggressive behavior, however, remains largely elusive. In this study, we identified …
Structural biology of glutamate receptor ion channels: towards an understanding of mechanism
IH Greger, ML Mayer - Current Opinion in Structural Biology, 2019 - Elsevier
Ionotropic glutamate receptors (iGluRs) are tetrameric ion channels that mediate signal
transmission at neuronal synapses, where they contribute centrally to the postsynaptic …
transmission at neuronal synapses, where they contribute centrally to the postsynaptic …
Genetic manipulations of AMPA glutamate receptors in hippocampal synaptic plasticity
R Gugustea, Z Jia - Neuropharmacology, 2021 - Elsevier
Abstract Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs)
are the principal mediators of fast excitatory synaptic transmission and they are required for …
are the principal mediators of fast excitatory synaptic transmission and they are required for …
Signal peptide represses GluK1 surface and synaptic trafficking through binding to amino-terminal domain
Kainate-type glutamate receptors play critical roles in excitatory synaptic transmission and
synaptic plasticity in the brain. GluK1 and GluK2 possess fundamentally different capabilities …
synaptic plasticity in the brain. GluK1 and GluK2 possess fundamentally different capabilities …
α2δ‐1 protein promotes synaptic expression of Ca2+ permeable–AMPA receptors by inhibiting GluA1/GluA2 heteromeric assembly in the hypothalamus in …
JJ Zhou, JY Shao, SR Chen, H Chen… - Journal of …, 2022 - Wiley Online Library
Glutamate AMPA receptors (AMPARs) lacking GluA2 subunit are calcium permeable (CP‐
AMPARs), which are increased in the hypothalamic paraventricular nucleus (PVN) and …
AMPARs), which are increased in the hypothalamic paraventricular nucleus (PVN) and …