Liver cancer is the second leading cause of cancer mortality worldwide, causing more than
700,000 deaths annually. Because of the wide landscape of genomic alterations and limited …

Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Liver metastases remain a major barrier to successful management of malignant disease,
particularly for cancers of the gastrointestinal tract but also for other malignancies, such as …

Tumours are known as wounds that do not heal—this implies that cells that are involved in
angiogenesis and the response to injury, such as endothelial cells and fibroblasts, have a …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Cancer associated fibroblasts (CAF) and the extracellular matrix (ECM) produced by them
have been recognized as key players in cancer biology and emerged as important targets …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Maintenance of both normal epithelial tissues and their malignant counterparts is supported
by the host tissue stroma. The tumor stroma mainly consists of the basement membrane …

The'seed and soil'hypothesis for metastasis sets forth the concept that a conducive
microenvironment, or niche, is required for disseminating tumour cells to engraft distant …

Models of liver fibrosis, which include cell culture models, explanted and biopsied human
material, and experimental animal models, have demonstrated that liver fibrosis is a highly …