Background The development of resistance is a problem shared by both classical
chemotherapy and targeted therapy. Patients may respond well at first, but relapse is …

Cutaneous wounds are a growing global health burden as a result of an aging population
coupled with increasing incidence of diabetes, obesity, and cancer. Cell-based approaches …

Abstract Galectin-1 (Gal-1) is involved in several pathological activities associated with
tumor progression and chemoresistance, however, the role and molecular mechanism of …

Integrins are heterodimeric glycoproteins crucial to the physiology and pathology of many
biological functions. As adhesion molecules, they mediate immune cell trafficking, migration …

Abstract β3 integrin (ITGB3), also known as CD61 or GP3A, is one of the most widely studied
components in the integrin family. As an adhesion receptor on the cell surface, ITGB3 …

Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory
mechanisms have evolved to maintain iron homeostasis within cells and between different …

Chemotherapy and targeted therapy have opened new avenues in clinical oncology.
However, there is a lack of response in a substantial percentage of cancer patients and …

Glioma is the most common primary brain tumor, accounting for 30% to 40% of all
intracranial tumors. About half of all gliomas in adults are glioblastomas. Patients with …

The chemotherapy of aggressive glioma is usually accompanied by a poor prognosis
because of the formation of vasculogenic mimicry (VM) and brain cancer stem cells …

Experimental and clinical studies over the past two decades have provided overwhelming
evidence that human cancers, including prostate cancer (PCa), harbor cancer stem cells …