The maintenance of cellular homeostasis and execution of regulatory mechanisms to
dynamically govern various cellular processes require the correct delivery of proteins to their …

Lysosomal degradation of ubiquitinated transmembrane protein receptors (cargo) relies on
the function of Endosomal Sorting Complex Required for Transport (ESCRT) protein …

The epidermal growth factor (EGF) receptor (EGFR) controls many aspects of cell
physiology. EGF binding to EGFR elicits the membrane recruitment and activation of …

Phosphoinositides represent a major class of lipids specifically involved in the organization
of signaling cascades, maintenance of the identity of organelles and regulation of multiple …

The non-receptor tyrosine kinases of the SRC family (SFK) play important roles in signal
transduction induced by a large variety of extracellular stimuli, including growth factors and …

The nonreceptor tyrosine kinases of the Src family (SFK) are frequently deregulated in
human colorectal cancer (CRC), and they have been implicated in tumour growth and …

ERBB2 overexpression in human breast cancer leads to invasive carcinoma but the
mechanism is not clearly understood. Here we report that TOM1L1 is co-amplified with …

Caveolin-1 (Cav-1) has been recently identified to be over-expressed in hepatocellular
carcinoma (HCC) and promote HCC cell motility and invasion ability via inducing epithelial …

It remains unclear how GPI-anchored proteins (GPIAPs), which lack cytoplasmic domains,
transduce signals triggered by specific ligation. Such signal transduction has been …

Signaling by growth factor receptor tyrosine kinases is manifest through networks of proteins
that are substrates and/or bind to the activated receptors. FGF receptor-3 (FGFR3) is a drug …