Advances in optical manipulation and observation of neural activity have set the stage for
widespread implementation of closed-loop and activity-guided optical control of neural …

To understand the organization and assembly of mammalian brain circuits, we need a
comprehensive tool set that can address the challenges of cellular diversity, spatial …

Microglia survey brain parenchyma, responding to injury and infections. Microglia also
respond to systemic disease, but the role of blood–brain barrier (BBB) integrity in this …

Microglia are the immune cells of the central nervous system that play important roles in
brain pathologies. Microglia also help shape neuronal circuits during development, via …

We describe a strategy for developing hydrophilic chemical cocktails for tissue delipidation,
decoloring, refractive index (RI) matching, and decalcification, based on comprehensive …

The development of whole-body imaging at single-cell resolution enables system-level
approaches to studying cellular circuits in organisms. Previous clearing methods focused on …

Minimal sets of transcription factors can directly reprogram somatic cells into neurons.
However, epigenetic remodeling during neuronal reprogramming has not been well …

Narcolepsy is a sleep disorder caused by deficiency of orexin signaling. However, the
neural mechanisms by which deficient orexin signaling causes the abnormal rapid eye …

Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and
memory. Accumulating evidence suggests that glia participates in sculpting the neuronal …

Optogenetics is among the most widely employed techniques to manipulate neuronal
activity. However, a major drawback is the need for invasive implantation of optical fibers. To …