Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

S Sivori, P Vacca, G Del Zotto, E Munari… - Cellular & molecular …, 2019 - nature.com
NK cells play important roles in innate defenses against viruses and in the control of tumor
growth and metastasis. The regulation/induction of NK cell function is mediated by an array …

Killer Ig-like receptors (KIRs): their role in NK cell modulation and developments leading to their clinical exploitation

D Pende, M Falco, M Vitale, C Cantoni… - Frontiers in …, 2019 - frontiersin.org
Natural killer (NK) cells contribute to the first line of defense against viruses and to the
control of tumor growth and metastasis spread. The discovery of HLA class I specific …

Balancing natural killer cell activation through paired receptors

L Martinet, MJ Smyth - Nature Reviews Immunology, 2015 - nature.com
Natural killer (NK) cells are innate lymphocytes that are crucial for the control of infections
and malignancies. NK cells express a variety of inhibitory and activating receptors that …

Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry

A Horowitz, DM Strauss-Albee, M Leipold… - Science translational …, 2013 - science.org
Natural killer (NK) cells play critical roles in immune defense and reproduction, yet remain
the most poorly understood major lymphocyte population. Because their activation is …

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs

V Béziat, LL Liu, JA Malmberg… - Blood, The Journal …, 2013 - ashpublications.org
Human natural killer (NK) cells are functionally regulated by killer cell immunoglobulin-like
receptors (KIRs) and their interactions with HLA class I molecules. As KIR expression in a …

Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution

P Parham, A Moffett - Nature Reviews Immunology, 2013 - nature.com
Natural killer (NK) cells have roles in immunity and reproduction that are controlled by
variable receptors that recognize MHC class I molecules. The variable NK cell receptors …

Uterine natural killer cells: functional distinctions and influence on pregnancy in humans and mice

LM Gaynor, F Colucci - Frontiers in immunology, 2017 - frontiersin.org
Our understanding of development and function of natural killer (NK) cells has progressed
significantly in recent years. However, exactly how uterine NK (uNK) cells develop and …

The shaping of modern human immune systems by multiregional admixture with archaic humans

L Abi-Rached, MJ Jobin, S Kulkarni, A McWhinnie… - Science, 2011 - science.org
Whole genome comparisons identified introgression from archaic to modern humans. Our
analysis of highly polymorphic human leukocyte antigen (HLA) class I, vital immune system …

Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2

SE Hiby, R Apps, AM Sharkey… - The Journal of …, 2010 - Am Soc Clin Investig
Many common disorders of pregnancy are attributed to insufficient invasion of the uterine
lining by trophoblast, fetal cells that are the major cell type of the placenta. Interactions …

Structure/function of human killer cell immunoglobulin‐like receptors: lessons from polymorphisms, evolution, crystal structures and mutations

KS Campbell, AK Purdy - Immunology, 2011 - Wiley Online Library
Stimulation or tolerance of natural killer (NK) cells is achieved through a cross‐talk of signals
derived from cell surface activating and inhibitory receptors. Killer cell immunoglobulin‐like …