miRNAs as Cornerstones in Chronic Lymphocytic Leukemia Pathogenesis and Therapeutic Resistance–An emphasis on the interaction of signaling pathways

AS Doghish, AI Abulsoud, SS Elshaer… - … -Research and Practice, 2023 - Elsevier
Chronic lymphocytic leukemia (CLL) accounts for the vast majority of cases of leukemia.
Patients of advanced age are more likely to develop the condition, which has a highly varied …

Clinical relevance of extracellular vesicles in hematological neoplasms: from liquid biopsy to cell biopsy

S Trino, D Lamorte, A Caivano, L De Luca, A Sgambato… - Leukemia, 2021 - nature.com
In the era of precision medicine, liquid biopsy is becoming increasingly important in
oncology. It consists in the isolation and analysis of tumor-derived biomarkers, including …

Exosome application in treatment and diagnosis of B-cell disorders: leukemias, multiple sclerosis, and arthritis rheumatoid

M Karami Fath, J Azami, N Jaafari… - Cellular & Molecular …, 2022 - Springer
Exosomes, known as a type of extracellular vesicles (EVs), are lipid particles comprising
heterogeneous contents such as nucleic acids, proteins, and DNA. These bi-layered …

MicroRNAs from liquid biopsy derived extracellular vesicles: recent advances in detection and characterization methods

R Drula, LF Ott, I Berindan-Neagoe, K Pantel, GA Calin - Cancers, 2020 - mdpi.com
Liquid biopsies have become a convenient tool in cancer diagnostics, real-time disease
monitoring, and evaluation of residual disease. Yet, the information still encrypted in the …

Extracellular vesicles in hematological malignancies: EV-dence for reshaping the tumoral microenvironment

D Van Morckhoven, N Dubois, D Bron… - Frontiers in …, 2023 - frontiersin.org
Following their discovery at the end of the 20th century, extracellular vesicles (EVs) ranging
from 50-1,000 nm have proven to be paramount in the progression of many cancers …

Long non-coding RNAs in myeloid malignancies

AA Zimta, C Tomuleasa, I Sahnoune, GA Calin… - Frontiers in …, 2019 - frontiersin.org
Acute myeloid leukemia (AML) represents 80% of adult leukemias and 15–20% of childhood
leukemias. AML are characterized by the presence of 20% blasts or more in the bone …

Extracellular vesicles in hematological malignancies: from biomarkers to therapeutic tools

J Khalife, JF Sanchez, F Pichiorri - Diagnostics, 2020 - mdpi.com
Small extracellular vesicles (EVs) are a heterogenous group of lipid particles released by all
cell types in physiological and pathological states. In hematological malignancies, tumor …

Uncovering the exosomes diversity: A window of opportunity for tumor progression monitoring

D Maisano, S Mimmi, R Russo, A Fioravanti, G Fiume… - Pharmaceuticals, 2020 - mdpi.com
Cells can communicate through special “messages in the bottle”, which are recorded in the
bloodstream inside vesicles, namely exosomes. The exosomes are nanovesicles of 30–100 …

Urinary microRNA in kidney disease: Utility and roles

IO Sun, LO Lerman - American Journal of Physiology-Renal …, 2019 - journals.physiology.org
MicroRNAs (miRNAs) are small, noncoding single-stranded RNA oligonucleotides that
modulate physiological and pathological processes by modulating target gene expression …

A review of macrophage micrornas' role in human asthma

G Feketea, CI Bocsan, C Popescu, M Gaman… - Cells, 2019 - mdpi.com
There is an imbalance in asthma between classically activated macrophages (M1 cells) and
alternatively activated macrophages (M2 cells) in favor of the latter. MicroRNAs (miRNAs) …