NOD-like receptor family pyrin domain containing 3 (NLRP3) is an intracellular receptor that
senses foreign pathogens and endogenous danger signals. It assembles with apoptosis …

Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

Innate immune response induces positive inflammatory transducers and regulators in order
to attack pathogens, while simultaneously negative signaling regulators are transcribed to …

It is now convincingly clear that diet is one of the most influential lifestyle factors contributing
to the rise of inflammatory diseases and autoimmunity in both developed and developing …

The zinc-dependent mammalian histone deacetylase (HDAC) family comprises 11 enzymes,
which have specific and critical functions in development and tissue homeostasis. Mounting …

Nutrients can reverse or change epigenetic phenomena such as DNA methylation and
histone modifications, thereby modifying the expression of critical genes associated with …

The intestinal microbiota is a complex microbial community, with diverse and stable
populations hosted by the gastrointestinal tract since birth. This ecosystem holds multiple …

Histone deacetylases (HDACs) are involved in diverse cellular regulatory mechanisms
including non-canonical functions outside the chromatin environment. Several publications …

Genome instability is a prerequisite for the development of cancer. It occurs when genome
maintenance systems fail to safeguard the genome's integrity, whether as a consequence of …

The ecosystem of the gut microbiota consists of diverse intestinal species with multiple
metabolic and immunologic activities and it is closely connected with the intestinal epithelia …