Structure-and ligand-based drug design: Concepts, approaches, and challenges
It takes more than 10 years to bring a drug to the market and costs an average cost of US
$2.6 billion. Computer-aided drug design (CADD) saves up to 30% of the time and money of …
$2.6 billion. Computer-aided drug design (CADD) saves up to 30% of the time and money of …
γδ T Cells: A Game Changer in the Future of Hepatocellular Carcinoma Immunotherapy
Hepatocellular carcinoma (HCC) remains a global health challenge with limited treatment
options and a poor prognosis for advanced-stage patients. Recent advancements in cancer …
options and a poor prognosis for advanced-stage patients. Recent advancements in cancer …
Stimuli-responsive, dual-function prodrug encapsulated in hyaluronic acid micelles to overcome doxorubicin resistance
Multidrug resistance (MDR) is the main challenge faced by cancer chemotherapy. Drug-
conjugate offers a promising strategy for breast cancer therapy. In this regard, we developed …
conjugate offers a promising strategy for breast cancer therapy. In this regard, we developed …
Immunoinformatics-based multi-epitope vaccine design for the re-emerging monkeypox virus
Abstract Background On May 7, 2022, WHO reported a new monkeypox case. By May 2023
over 80,000 cases had been reported worldwide outside previously endemic nations.(This …
over 80,000 cases had been reported worldwide outside previously endemic nations.(This …
Silencing of long non-coding RNA HCP5 inhibits proliferation, invasion, migration, and promotes apoptosis via regulation of miR-299-3p/SMAD5 axis in gastric cancer …
D Yin, X Lu - Bioengineered, 2021 - Taylor & Francis
Gastric cancer (GC) is a common malignant gastrointestinal tumor with high mortality.
Previous study has reported that the overexpression of lncRNA HCP5 was observed in …
Previous study has reported that the overexpression of lncRNA HCP5 was observed in …
Searching for natural Aurora a kinase inhibitors from peppers using molecular docking and molecular dynamics
P Siudem, Ł Szeleszczuk, K Paradowska - Pharmaceuticals, 2023 - mdpi.com
Natural products are the precursors of many medicinal substances. Peppers (Piper,
Capsicum, Pimienta) are a rich source of compounds with potential multidirectional …
Capsicum, Pimienta) are a rich source of compounds with potential multidirectional …
Exploring the binding interaction of Raf kinase inhibitory protein with the N-terminal of C-Raf through molecular docking and molecular dynamics simulation
Protein-protein interactions are indispensable physiological processes regulating several
biological functions. Despite the availability of structural information on protein-protein …
biological functions. Despite the availability of structural information on protein-protein …
In silico investigation of nonsynonymous single nucleotide polymorphisms in BCL2 apoptosis regulator gene to design novel protein‐based drugs against cancer
MM Fareed, K Dutta, T Dandekar… - Journal of Cellular …, 2022 - Wiley Online Library
BCL2 apoptosis regulator gene encodes Bcl‐2 pro‐survival protein, which plays an
important role to evade apoptosis in various cancers. Moreover, single nucleotide …
important role to evade apoptosis in various cancers. Moreover, single nucleotide …
Methionine enkephalin inhibited cervical carcinoma via apoptosis promotion and reduction of myeloid derived suppressor cell infiltrated in tumor
N Qu, R Wang, Y Meng, N Liu, J Zhai, F Shan - International …, 2022 - Elsevier
Immunotherapy for cervical carcinoma is becoming increasingly important recently. In these
studies methionine enkephalin (menk) is shown to inhibit cervical tumor cell proliferation in …
studies methionine enkephalin (menk) is shown to inhibit cervical tumor cell proliferation in …
A new Pd (II) complex containing acetophenone oxime and 1, 3-Bis (diphenylphosphino) propane ligands; crystal structure, catalytic activity, molecular docking and in …
A new palladium (II) complex of the type [Pd {C, NC 6 H 4 {C (Me)= NOH}-2}(dppp)] ClO 4 (2)
has been prepared by the reaction of the cyclopalladated oxime complex [Pd {C, NC 6 H 4 …
has been prepared by the reaction of the cyclopalladated oxime complex [Pd {C, NC 6 H 4 …