Recently, William Proctor and colleagues have published a comprehensive study about the
use human hepatocyte spheroids to predict DILI in patients (Proctor et al. 2017). This is a …

C max values. At a first glance, one may ask, whether it is really justified to introduce another
liver tumor cell line besides the already well-established HepG2 and HepaRG cells …

Over the past decade much effort has been invested into the development of in vitro systems
as alternatives to animal experiments (Hammad et al., 2013, 2014a, b; Hammad, 2013; …

Recently, several articles have been published questioning the usefulness of animal
experiments for prediction of human toxicity (Leist and Hartung, 2013). For example, it has …

Publicly available datasets have been particularly often used in clinical cancer research to
identify prognostic genes (Schmidt et al. 2008, 2012; Cadenas et al. 2010, 2014; Stewart et …

Recently, novel image processing and analysis software named TiQuant has been
published that allows for reconstruction and quantification of biological tissue from common …

Over the past decade much effort has been invested into the development of in vitro systems
as alternatives to animal experiments (Hammad et al., 2013, 2014a, b; Hammad, 2013; …

Recently, several articles have been published questioning the usefulness of animal
experiments for prediction of human toxicity (Leist and Hartung, 2013). For example, it has …