Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria

YM Shi, M Hirschmann, YN Shi, S Ahmed… - Nature Chemistry, 2022 - nature.com
Microorganisms contribute to the biology and physiology of eukaryotic hosts and affect other
organisms through natural products. Xenorhabdus and Photorhabdus (XP) living in …

Beyond soil-dwelling actinobacteria: Fantastic antibiotics and where to find them

J Santos-Aberturas, NM Vior - Antibiotics, 2022 - mdpi.com
Bacterial secondary metabolites represent an invaluable source of bioactive molecules for
the pharmaceutical and agrochemical industries. Although screening campaigns for the …

Metabolomics and Genomics Enable the Discovery of a New Class of Nonribosomal Peptidic Metallophores from a Marine Micromonospora

Q Wu, BA Bell, JX Yan, MG Chevrette… - Journal of the …, 2022 - ACS Publications
Although microbial genomes harbor an abundance of biosynthetic gene clusters, there
remain substantial technological gaps that impair the direct correlation of newly discovered …

Toxicity of Photorhabdus luminescens and Xenorhabdus bovienii bacterial metabolites to pecan aphids (Hemiptera: Aphididae) and the lady beetle Harmonia axyridis …

S Wu, MD Toews, TE Cottrell, JM Schmidt… - Journal of Invertebrate …, 2022 - Elsevier
Toxicity of the metabolites of two bacteria, Photorhabdus luminescens and Xenorhabdus
bovienii, symbionts of entomopathogenic nematodes, were tested in the laboratory against …

Paenibacillus caseinilyticus sp. nov., isolated forest soil

H Lee, DK Chaudhary, OB Lim… - … of Systematic and …, 2023 - microbiologyresearch.org
A milky-white-coloured, aerobic, Gram-stain-positive, rod-shaped and motile bacterial strain
(GW78T) was isolated from forest soil. GW78T was catalase-positive and oxidase-negative …

Mining Biosynthetic Gene Clusters of Pseudomonas vancouverensis Utilizing Whole Genome Sequencing

P Tamang, A Upadhaya, P Paudel, K Meepagala… - Microorganisms, 2024 - mdpi.com
Natural product (NP)-based pesticides have emerged as a compelling alternative to
traditional chemical fungicides, attracting substantial attention within the agrochemical …

Comprehensive phenomic and genomic studies of the species, Pectobacterium cacticida and proposal for reclassification as Alcorniella cacticida comb. nov

J Jonca, M Pirhonen, MM Waleron, J Gawor… - Frontiers in plant …, 2024 - frontiersin.org
Introduction Pectobacterium cacticida was identified as the causative agent of soft rot
disease in cacti. Due to a high potential of spread in the face of global warming, the species …

The Xenorhabdus nematophila LrhA transcriptional regulator modulates production of γ-keto-N-acyl amides with inhibitory activity against mutualistic host nematode …

YC Lam, R Hamchand, NC Mucci… - Applied and …, 2024 - journals.asm.org
Xenorhabdus nematophila is a symbiotic Gammaproteobacterium that produces diverse
natural products that facilitate mutualistic and pathogenic interactions in their nematode and …

Analyses of Xenorhabdus griffiniae genomes reveal two distinct sub-species that display intra-species variation due to prophages

JK Heppert, RM Awori, M Cao, G Chen, J McLeish… - BMC genomics, 2024 - Springer
Background Nematodes of the genus Steinernema and their Xenorhabdus bacterial
symbionts are lethal entomopathogens that are useful in the biocontrol of insect pests, as …

Structure of a Putative Terminal Amidation Domain in Natural Product Biosynthesis

MR Rankin, D Khare, L Gerwick, DH Sherman… - bioRxiv, 2024 - biorxiv.org
Bacteria are rich sources of pharmaceutically valuable natural products, many crafted by
modular polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS). PKS …