Circular RNA as a novel biomarker and therapeutic target for HCC

H Meng, R Niu, C Huang, J Li - Cells, 2022 - mdpi.com
Circular RNA (circRNA) is a kind of endogenous non-coding RNA (ncRNA), which is
produced by the reverse splicing of precursor mRNA (pre mRNA). It is widely expressed in a …

Circular RNAs with protein-coding ability in oncogenesis

J Cheng, G Li, W Wang, DB Stovall, G Sui… - Biochimica et Biophysica …, 2023 - Elsevier
As ubiquitously expressed transcripts in eukaryotes, circular RNAs (circRNAs) are covalently
closed and lack a 5′-cap and 3′-polyadenylation (poly (A)) tail. Initially, circRNAs were …

CircGPRC5A enhances colorectal cancer progress by stabilizing PPP1CA and inducing YAP dephosphorylation

Z Chen, Y Li, K He, J Yang, Q Deng, Y Chen… - Journal of Experimental & …, 2023 - Springer
Background With the advancements in bioinformatic technology, an increasing number of
circular RNAs (circRNAs) have been discovered and their crucial roles in the development …

Long non-coding HOXA-AS3 contributes to osteosarcoma progression through the miR-1286/TEAD1 axis

X Xiao, M Liu, S Xie, C Liu, X Huang… - Journal of Orthopaedic …, 2023 - Springer
Long non-coding RNA (lncRNA) HOXA cluster antisense RNA 3 (HOXA-AS3) regulates the
progression of several types of human malignancy. However, the role and potential …

The function and regulation network mechanism of circRNA in liver diseases

P Wang, Y Zhang, L Deng, Z Qu, P Guo, L Liu… - Cancer Cell …, 2022 - Springer
Circular RNA (circRNA), a new type of endogenous non-coding RNA, is abundantly present
in eukaryotic cells, and characterized as stable high conservation and tissue specific …

KLF14/miR‐1283/TFAP2C axis inhibits HER2‐positive breast cancer progression via declining tumor cell proliferation

XZ Chen, WX He, RG Luo, GJ Xia… - Molecular …, 2023 - Wiley Online Library
MiR‐1283 has been identified as a tumor suppressor in some malignancies. Whereas, the
role of miR‐1283 in HER2‐positive (HER2+) breast cancer, particularly its role in regulating …

TEA domain transcription factor 1 inhibits ferroptosis and sorafenib sensitivity of hepatocellular carcinoma cells

H Li, H Lan, M Zhang, F Zhao, N An, C Yi - Digestive Diseases and …, 2023 - Springer
Background Ferroptosis, as a unique form of cell death, plays crucial negative roles in
tumorigenesis and progression. This study aimed to investigate the role and molecular …

Recent update on the role of circular RNAs in hepatocellular carcinoma

A Ely, K Bloom, MB Maepa… - Journal of Hepatocellular …, 2021 - Taylor & Francis
After being overlooked for decades, circular RNAs (circRNAs) have recently generated
considerable interest. circRNAs play a role in a variety of normal and pathological biological …

Hepatocellular Carcinoma: Up-regulated Circular RNAs Which Mediate Efficacy in Preclinical In Vivo Models

UH Weidle, A Nopora - Cancer Genomics & Proteomics, 2023 - cgp.iiarjournals.org
Hepatocellular carcinoma (HCC) ranges as number two with respect to the incidence of
tumors and is associated with a dismal prognosis. The therapeutic efficacy of approved multi …

Circ_0091579 Knockdown Inhibited HCC Proliferation and Glutamine Metabolism Through miR-1270/YAP1 Axis

M Liu, B Guo, G Zhang, H Qi - Biochemical Genetics, 2024 - Springer
A growing number of studies have indicated that circRNAs play an important role in the
progression of malignant tumors, including hepatocellular carcinoma (HCC). In this study …