Triazole derivatives and their anti-tubercular activity

S Zhang, Z Xu, C Gao, QC Ren, L Chang, ZS Lv… - European journal of …, 2017 - Elsevier
Tuberculosis (TB) remains one of the most widespread and leading deadliest diseases,
threats one-third of the world's population. Although numerous efforts have been undertaken …

CuAAC-ensembled 1, 2, 3-triazole-linked isosteres as pharmacophores in drug discovery

A Rani, G Singh, A Singh, U Maqbool, G Kaur… - RSC advances, 2020 - pubs.rsc.org
The review lays emphasis on the significance of 1, 2, 3-triazoles synthesized via CuAAC
reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory …

Hybrid molecules: The privileged scaffolds for various pharmaceuticals

S Mishra, P Singh - European journal of medicinal chemistry, 2016 - Elsevier
The practice of polypharmacology is not a new concept but the approaches which are being
adopted for administering the two or more drugs together are varied from time to time …

Antibacterial and antioxidant activities for natural and synthetic dual-active compounds

G Martelli, D Giacomini - European Journal of Medicinal Chemistry, 2018 - Elsevier
Antimicrobial resistance is widely recognized as a grave threat to global health in the 21st
century, since the past decades have seen a dramatic increase in human-pathogenic …

Design and synthesis of novel 1, 2, 3-triazole-dithiocarbamate hybrids as potential anticancer agents

YC Duan, YC Ma, E Zhang, XJ Shi, MM Wang… - European journal of …, 2013 - Elsevier
A series of novel 1, 2, 3-triazole-dithiocarbamate hybrids were designed, synthesized and
evaluated for anticancer activity against four selected human tumor cell lines (MGC-803 …

Benzofuran derivatives and their anti-tubercular, anti-bacterial activities

Z Xu, S Zhao, Z Lv, L Feng, Y Wang, F Zhang… - European Journal of …, 2019 - Elsevier
Benzofuran is a fundamental structural unit in a variety of biologically active natural
products, and its derivatives display various biological properties. Some benzofuran …

Emerging impact of triazoles as anti-tubercular agent

A Sharma, AK Agrahari, S Rajkhowa… - European Journal of …, 2022 - Elsevier
Tuberculosis, a disease of poverty is a communicable infection with a reasonably high
mortality rate worldwide. 10 Million new cases of TB were reported with approx 1.4 million …

Triazole: a promising antitubercular agent

RS Keri, SA Patil, S Budagumpi… - Chemical biology & …, 2015 - Wiley Online Library
Tuberculosis is a contagious disease with comparatively high mortality worldwide. The
statistics shows that around three million people throughout the world die annually from …

Design, synthesis, and structure–activity relationship of novel LSD1 inhibitors based on pyrimidine–thiourea hybrids as potent, orally active antitumor agents

LY Ma, YC Zheng, SQ Wang, B Wang… - Journal of medicinal …, 2015 - ACS Publications
Histone lysine specific demethylase 1 (LSD1) was reported to be overexpressed in several
human cancers and recognized as a promising anticancer drug target. In the current study …

Recent advancements in 1, 4-disubstituted 1H-1, 2, 3-triazoles as potential anticancer agents

K Lal, P Yadav - Anti-Cancer Agents in Medicinal Chemistry …, 2018 - ingentaconnect.com
Cancer is a class of formidable disease with high degree of mortality. Despite much
progress in chemotherapy, the problem of drug resistance has led to the search for newer …