Metastasis accounts for the vast majority of morbidity and mortality associated with
melanoma. Evidence suggests melanoma has a predilection for metastasis to particular …

Uveal melanoma (UM) is a type of intraocular tumor with a propensity to disseminate to the
liver. Despite the identification of the early driver mutations during the development of the …

Uveal melanoma is the most common primary intraocular malignant tumor in adults and half
of the primary tumors will develop fatal metastatic disease to the liver and the lung …

Metastatic dormancy of melanoma has not received sufficient attention, most likely because
once detectable, metastasis is almost invariably fatal and, understandably, the focus has …

Importance To the best of my knowledge, this study demonstrates for the first time small,
apparently dormant micrometastasis in the liver of patients with uveal melanoma. Objective …

Despite extensive research and refined therapeutic options, the survival for metastasized
uveal melanoma (UM) patients has not improved significantly. UM, a malignant tumor …

Simple Summary Metastatic Uveal Melanoma (MUM) is a lethal malignancy with no durable
treatment available to date. A vast majority of patients with MUM present with liver …

Distant metastases (MET) are for most solid cancers decisive life-threatening events. Data
about MET-free survival and survival after MET show a strong dependency on the kind of …

The UPR (unfolded protein response) has been identified as a key factor in the progression
and metastasis of cancers, notably melanoma. Several mediators of the UPR are …

Acta Ophthalmol. 2011: 89: 17–24 Abstract. Purpose: To evaluate whether tumour therapy
for malignant uveal melanoma leads to a shedding of melanoma cells into the systemic …