Hematopoietic SCT with cryopreserved grafts: adverse reactions after transplantation and cryoprotectant removal before infusion

Z Shu, S Heimfeld, D Gao - Bone marrow transplantation, 2014 - nature.com
Transplantation of hematopoietic stem cells (HSCs) has been successfully developed as a
part of treatment protocols for a large number of clinical indications, and cryopreservation of …

Adverse reactions of dimethyl sulfoxide in humans: a systematic review

BK Madsen, M Hilscher, D Zetner… - …, 2019 - pmc.ncbi.nlm.nih.gov
Background: Dimethyl sulfoxide (DMSO) has been used for medical treatment and as a
pharmacological agent in humans since the 1960s. Today, DMSO is used mostly for …

Adult stem cells and diseases of aging

LB Boyette, RS Tuan - Journal of clinical medicine, 2014 - mdpi.com
Preservation of adult stem cells pools is critical for maintaining tissue homeostasis into old
age. Exhaustion of adult stem cell pools as a result of deranged metabolic signaling …

Cardiac and cardiovascular consequences after haematopoietic stem cell transplantation

A Tichelli, S Bhatia, G Socié - British journal of haematology, 2008 - Wiley Online Library
Haematopoietic stem cell transplantation (HCT) is the treatment of choice for defined
malignant and non‐malignant haematological disorders. The main drawbacks of HCT are …

Manufacturing and banking of mesenchymal stem cells

S Thirumala, WS Goebel, EJ Woods - Expert opinion on biological …, 2013 - Taylor & Francis
Introduction: Mesenchymal stem cells (MSC) and MSC-like cells hold great promise and
offer many advantages for developing effective cellular therapeutics. Current trends indicate …

Historical perspectives and the future of adverse reactions associated with haemopoietic stem cells cryopreserved with dimethyl sulfoxide

MA Cox, J Kastrup, M Hrubiško - Cell and tissue banking, 2012 - Springer
A retrospective review of the published literature identified several hundred adverse
reactions (eg nausea, chills, cardiac arrhythmias, neurological symptoms and respiratory …

Hematopoietic engraftment of dimethyl sulfoxide–depleted autologous peripheral blood progenitor cells

ÇA Akkök, MR Holte, JM Tangen, B Østenstad… - …, 2009 - Wiley Online Library
BACKGROUND: Autologous stem cell transplantation with cryopreserved autografts is a
prerequisite for high‐dose chemotherapy in treatment of several malignancies. Adverse …

Use of different DMSO concentrations for cryopreservation of autologous peripheral blood stem cell grafts does not have any major impact on levels of leukocyte-and …

ÇA Akkök, K Liseth, T Hervig, A Ryningen, Ø Bruserud… - Cytotherapy, 2009 - Elsevier
Background aims Infusion of stem cell autografts can be associated with adverse effects.
Necrotic normal leukocytes, cytokines or intracellular mediators released from leukocytes …

Adverse events of cryopreserved hematopoietic stem cell infusions in adults: a single‐center observational study

ZK Otrock, DS Sempek, S Carey, BJ Grossman - Transfusion, 2017 - Wiley Online Library
BACKGROUND Autologous hematopoietic stem cell (HSC) transplantation has been used
for almost three decades for the management of malignant hematologic diseases and some …

Adverse reactions during transfusion of thawed haematopoietic progenitor cells from apheresis are closely related to the number of granulocyte cells in the …

GA Martín‐Henao, PM Resano, JMS Villegas… - Vox …, 2010 - Wiley Online Library
Background and Objectives The infusion of thawed haematopoietic progenitor cells from
apheresis (HPC‐A) is associated with minor but frequent adverse reactions (ARs), which …