Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis

TS Kang, D Georgieva, N Genov… - The FEBS …, 2011 - Wiley Online Library
Snake venoms are cocktails of enzymes and non‐enzymatic proteins used for both the
immobilization and digestion of prey. The most common snake venom enzymes include …

The biological significance of substrate inhibition: a mechanism with diverse functions

MC Reed, A Lieb, HF Nijhout - Bioessays, 2010 - Wiley Online Library
Many enzymes are inhibited by their own substrates, leading to velocity curves that rise to a
maximum and then descend as the substrate concentration increases. Substrate inhibition is …

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

K Haga, AC Kruse, H Asada, T Yurugi-Kobayashi… - Nature, 2012 - nature.com
The parasympathetic branch of the autonomic nervous system regulates the activity of
multiple organ systems. Muscarinic receptors are G-protein-coupled receptors that mediate …

Comparison of the binding of reversible inhibitors to human butyrylcholinesterase and acetylcholinesterase: A crystallographic, kinetic and calorimetric study

TL Rosenberry, X Brazzolotto, IR Macdonald… - Molecules, 2017 - mdpi.com
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) hydrolyze the
neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic …

Acetylcholinesterase: how is structure related to function?

I Silman, JL Sussman - Chemico-biological interactions, 2008 - Elsevier
In accordance with its biological role, termination of neurotransmission at cholinergic
synapses by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase is …

[图书][B] Textbook of drug design and discovery

K Stromgaard, P Krogsgaard-Larsen, U Madsen - 2009 - taylorfrancis.com
The molecular biological revolution and the mapping of the human genome continue to
provide new challenges and opportunities for drug research and design. Future medicinal …

Qualitative and quantitative structure activity relationships for the inhibitory effects of cationic head groups, functionalised side chains and anions of ionic liquids on …

J Arning, S Stolte, A Böschen, F Stock, WR Pitner… - Green …, 2008 - pubs.rsc.org
To contribute to a deeper insight into the hazard potential of ionic liquids to humans and the
environment, an acetylcholinesterase (AchE) inhibition screening assay was used to identify …

Structure and function of an insect α-carboxylesterase (αEsterase7) associated with insecticide resistance

CJ Jackson, JW Liu, PD Carr… - Proceedings of the …, 2013 - National Acad Sciences
Insect carboxylesterases from the α Esterase gene cluster, such as αE7 (also known as E3)
from the Australian sheep blowfly Lucilia cuprina (Lc αE7), play an important physiological …

Acetylcholinesterase: a versatile template to coin potent modulators of multiple therapeutic targets

FJ Luque, D Muñoz-Torrero - Accounts of Chemical Research, 2024 - ACS Publications
Conspectus The enzyme acetylcholinesterase (AChE) hydrolyzes the neurotransmitter
acetylcholine (ACh) at cholinergic synapses of the peripheral and central nervous system …

Acaricidal activity, biochemical effects and molecular docking of some monoterpenes against two-spotted spider mite (Tetranychus urticae Koch)

SAM Abdelgaleil, MEI Badawy, NF Mahmoud… - Pesticide biochemistry …, 2019 - Elsevier
Abstract Six natural monoterpenes (1, 8-cineole,(-)-citronellal, limonene, α-pinene, pulegone
and 4-terpineol) showed high acaricidal activity by fumigant and contact actions against …