The accumulation of stalled translation preinitiation complexes (PICs) mediates the
condensation of stress granules (SGs). Interactions between prion-related domains and …

Complex biological systems and cellular networks may underlie most genotype to
phenotype relationships. Here, we review basic concepts in network biology, discussing …

Allosteric regulation of protein function is widespread in biology, but is challenging for de
novo protein design as it requires the explicit design of multiple states with comparable free …

This review describes the family of intrinsically disordered proteins, members of which fail to
form rigid 3-D structures under physiological conditions, either along their entire lengths or …

The abundant existence of proteins and regions that possess specific functions without
being uniquely folded into unique 3D structures has become accepted by a significant …

Transient interactions, which involve protein interactions that are formed and broken easily,
are important in many aspects of cellular function. Here we describe structural and functional …

The ideas that proteins might possess specific functions without being uniquely folded into
rigid 3D-structures and that these floppy polypeptides might constitute a noticeable part of …

It is clear now that eukaryotic cells contain numerous membrane-less organelles, many of
which are formed in response to changes in the cellular environment. Being typically liquid …

It is recognized now that various proteinaceous membrane‐less organelles (PMLOs) are
commonly found in cytoplasm, nucleus, and mitochondria of various eukaryotic cells (as well …

Transient complexes are crucial for diverse biological processes such as biochemical
pathways and signaling cascades in the cell. Here, we give an overview of the transient …