Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens
A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …
Coronavirus accessory protein ORF3 biology and its contribution to viral behavior and pathogenesis
Coronavirus porcine epidemic diarrhea virus (PEDV) is classified in the genus
Alphacoronavirus, family Coronaviridae that encodes the only accessory protein, ORF3 …
Alphacoronavirus, family Coronaviridae that encodes the only accessory protein, ORF3 …
Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning
CE Radford, P Schommers, L Gieselmann… - Cell Host & Microbe, 2023 - cell.com
Understanding the specificities of human serum antibodies that broadly neutralize HIV can
inform prevention and treatment strategies. Here, we describe a deep mutational scanning …
inform prevention and treatment strategies. Here, we describe a deep mutational scanning …
Analysis of glycosylation and disulfide bonding of wild-type SARS-CoV-2 spike glycoprotein
ABSTRACT The SARS-CoV-2 coronavirus, the etiologic agent of COVID-19, uses its spike
(S) glycoprotein anchored in the viral membrane to enter host cells. The S glycoprotein is the …
(S) glycoprotein anchored in the viral membrane to enter host cells. The S glycoprotein is the …
Characterization of the human immunodeficiency virus (HIV-1) envelope glycoprotein conformational states on infectious virus particles
ABSTRACT Human immunodeficiency virus (HIV-1) entry into cells involves triggering of the
viral envelope glycoprotein (Env) trimer ([gp120/gp41] 3) by the primary receptor, CD4, and …
viral envelope glycoprotein (Env) trimer ([gp120/gp41] 3) by the primary receptor, CD4, and …
Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein …
The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer mediates
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …
A multidonor class of highly glycan-dependent HIV-1 gp120-gp41 interface-targeting broadly neutralizing antibodies
Antibodies that target the gp120-gp41 interface of the HIV-1 envelope (Env) trimer comprise
a commonly elicited category of broadly neutralizing antibodies (bNAbs). Here, we isolate …
a commonly elicited category of broadly neutralizing antibodies (bNAbs). Here, we isolate …
Shedding-resistant HIV-1 envelope glycoproteins adopt downstream conformations that remain responsive to conformation-preferring ligands
The human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer of
gp120-gp41 heterodimers mediates virus entry into CD4-positive (CD4+) cells. Single …
gp120-gp41 heterodimers mediates virus entry into CD4-positive (CD4+) cells. Single …
The glycan hole area of HIV-1 envelope trimers contributes prominently to the induction of autologous neutralization
A Schorcht, CA Cottrell, P Pugach, RP Ringe… - Journal of …, 2022 - Am Soc Microbiol
The human immunodeficiency virus type 1 (HIV-1) trimeric envelope glycoprotein (Env) is
heavily glycosylated, creating a dense glycan shield that protects the underlying peptidic …
heavily glycosylated, creating a dense glycan shield that protects the underlying peptidic …
Functional and highly cross-linkable HIV-1 envelope glycoproteins enriched in a pretriggered conformation
Binding to the receptor, CD4, drives the pretriggered,“closed”(state-1) conformation of the
human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer into more …
human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer into more …