Virus-like particles (VLPs) are multiprotein structures that mimic the organization and
conformation of authentic native viruses but lack the viral genome, potentially yielding safer …

Compared to traditional chromatography using resins in packed-bed columns, membrane
chromatography is a relatively new and immature bioseparation technology based on the …

Virus-like particles (VLPs) hold tremendous potential as vaccine candidates. These
innovative biopharmaceuticals present the remarkable advantages of closely mimicking the …

Introduction: The development of novel complex biotherapeutics led to new challenges in
biopharmaceutical industry. The potential of these particles has been demonstrated by the …

The baculovirus‐insect cell expression system is widely used in producing recombinant
proteins. This review is focused on the use of this expression system in developing …

Virus-like particles (VLPs) are self-assembled structures derived from viral antigens that
mimic the native architecture of viruses but lack the viral genome. VLPs have emerged as a …

Affinity chromatography is among the most powerful separation techniques, achieving the
finest separation with high yields even in the most challenging feed streams. Incorporating …

The downstream processing of virus particles for vaccination or gene therapy is becoming a
critical bottleneck as upstream titers keep improving. Moreover, the growing pressure to …

Expression of recombinant vaccine antigens and monoclonal antibodies using plant viral
vectors has developed extensively during the past several years. The approach benefits …

Manufacturing of cell culture-derived virus particles for vaccination and gene therapy is a
rapidly growing field in the biopharmaceutical industry. The process involves a number of …