Bipolar disorders (BDs) are recurrent and sometimes chronic disorders of mood that affect
around 2% of the world's population and encompass a spectrum between severe elevated …

Depression in bipolar disorder (BD) patients presents major clinical challenges. As the
predominant psychopathology even in treated BD, depression is associated not only with …

We summarize evidence supporting contemporary pharmacological treatment of phases of
BD, including: mania, depression, and long-term recurrences, emphasizing findings from …

Background The role of environmental risk factors in the development of bipolar disorder
(BD) is not well characterized. We evaluate the prevalence, duration, and predictive value of …

These guidelines for the treatment of unipolar depressive disorders systematically review
available evidence pertaining to the biological treatment of patients with major depression …

Neuropsychiatric signs and symptoms occur frequently in individuals with multiple sclerosis
(MS), either as the initial presenting complaint prior to a definitive neurological diagnosis or …

Objective Recent massive investment in electronic health records (EHRs) was predicated on
the assumption of improved patient safety, research capacity, and cost savings. However …

Objective Some people with major depressive disorder (MDD) may be at a pre‐onset stage
for bipolar disorder (BD), where early identification or prevention efforts may be feasible. We …

Mood disorders are often characterised by alterations in circadian rhythms, sleep
disturbances and seasonal exacerbation. Conversely, chronobiological treatments utilise …

The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision
(DSM-IV-TR) nomenclature for the co-occurrence of manic and depressive symptoms (mixed …