Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and
inflammatory response but also affects hematopoiesis, metabolism, and organ development …

Systemic lupus erythematosus (SLE) is an autoimmune disease with manifestations derived
from the involvement of multiple organs including the kidneys, joints, nervous system and …

Lupus nephritis (LN), a potentially destructive outcome of SLE, is a real challenge in the
management of SLE because of the difficulty in diagnosing its subclinical onset and …

T cells contribute to the initiation and perpetuation of autoimmunity in systemic lupus
erythematosus (SLE), and seem to be directly involved in the development of related organ …

Advances in genetics, such as sequencing of the human genome, have contributed to
identification of susceptible genetic patterns in autoimmune diseases (AID). However …

Lupus nephritis (LN) represents the most severe organ manifestation of systemic lupus
erythematosus (SLE) in terms of morbidity and mortality. To reduce these risks, tremendous …

IL-6 is considered one of the well characterized cytokines exhibiting homeostatic, pro-and
anti-inflammatory activities, depending on the receptor variant and the induced intracellular …

Chronic inflammation induced by biological, chemical, and physical factors has been found
to be associated with the increased risk of cancer in various organs. We revealed that …

The innate immune response provides a first line of defense against common
microorganisms and, for more complex and/or recurring situations where pathogens must be …

The pathogenic origin of autoimmune diseases can be traced to both genetic susceptibility
and epigenetic modifications arising from exposure to the environment. Epigenetic …