In addition to oxidative phosphorylation (OXPHOS), mitochondria perform other functions
such as heme biosynthesis and oxygen sensing and mediate calcium homeostasis, cell …

Cerebral ischemia results in a poor oxygen supply and cerebral infarction. Reperfusion to
the ischemic area is the best therapeutic approach. Although reperfusion after ischemia has …

The purpose of our study was to better understand the effects of mitochondrial-division
inhibitor 1 (Mdivi-1) on mitochondrial fission, mitochondrial biogenesis, electron transport …

Neuronal cytotoxic edema is the morphological correlate of the near-complete neuronal
battery breakdown called spreading depolarization, or conversely, spreading depolarization …

Neurons are highly polarised, complex and incredibly energy intensive cells, and their
demand for ATP during neuronal transmission is primarily met by oxidative phosphorylation …

Central nervous system (CNS) diseases, both traumatic and neurodegenerative, are
characterized by impaired mitochondrial bioenergetics and often disturbed mitochondrial …

Reactive oxygen species (ROS; eg., superoxide [O2•−] and hydrogen peroxide [H2O2]) and
reactive nitrogen species (RNS; eg., nitric oxide [NO•]) at the physiological level function as …

Mitochondria are essential cytoplasmic organelles, critical for cell survival and death. Recent
mitochondrial research revealed that mitochondrial dynamics—the balance of fission and …

Mitochondria are the primary source of energy production in the brain thereby supporting
most of its activity. However, mitochondria become inefficient and dysfunctional with age and …

Mitochondrial dynamics is a complex process, which involves the fission and fusion of
mitochondrial outer and inner membranes. These processes organize the mitochondrial size …