B cell subsets differ in development, tissue distribution, and mechanisms of activation. In
response to infections, however, all can differentiate into extrafollicular plasmablasts that …

The cytokine Fms-like tyrosine kinase 3 ligand (FL) is an important regulator of
hematopoiesis. Its receptor, Flt3, is expressed on myeloid, lymphoid and dendritic cell …

We have demonstrated that modifying the tumor microenvironment through intratumoral
administration of adenoviral vectors (Ad) encoding the conditional cytotoxic molecule, ie …

Cytokines are essential regulators of hematopoiesis, acting in an instructive or permissive
way. Fms-like tyrosine kinase 3 ligand (FLT3L) is an important cytokine for the development …

Defining differentiation pathways is central to understanding the pathogenesis of
hematopoietic disorders, including leukemia. The function of the receptor tyrosine kinase …

Mice deficient in c-fms–like tyrosine kinase 3 (FLT3) signaling have reductions in early
multipotent and lymphoid progenitors, whereas no evident myeloid phenotype has been …

Assessment of circulating biomarkers for potential pharmacodynamic utility in patients with
lymphoma | British Journal of Cancer Skip to main content Thank you for visiting nature.com …

Hematopoietic stem cell transplantation (HSCT) requires conditioning treatments such as
irradiation, which leads to a severely delayed recovery of T cell immunity and constitutes a …

Given that FLT 3 expression is highly restricted on lymphoid progenitors, it is possible that
the established role of FLT 3 in the regulation of B and T lymphopoiesis reflects its high …

Originally cloned from hematopoietic stem cell (HSC) populations and its ligand being
extensively used to promote ex vivo HSC expansion, the FMS-like tyrosine kinase 3 (FLT3; …